Ultrafast enzymatic reaction dynamics in protochlorophyllide oxidoreductase
Ultrafast enzymatic reaction dynamics in protochlorophyllide oxidoreductase
复制标题
原叶绿素内酯氧化还原酶的超快酶反应动力学
DOI：
--
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Groot
中科院分区：
文献类型：
--
作者：
D. Heyes;C. Hunter;I. V. Stokkum;R. Grondelle;M. Groot
光驱动的酶原叶绿素氧化还原酶（POR）催化的反应已开始与50飞秒激光脉冲。我们表明，催化机制，涉及质子和氢化物转移，进行与3 ps和400 ps的时间常数。众所周知，POR的催化作用涉及热激发的蛋白质动力学;我们的结果表明，这些分子运动发生在超快的时间尺度上。注意事项：这篇论文最初在网上发表的版本被错误地标记为“文章”;正确的类别应该是“简短的交流”。由此给您带来的不便我们深表歉意。这个错误已经在HTML和打印版本的文件中得到纠正。
The reaction catalyzed by the light-driven enzyme protochlorophyllide oxidoreductase (POR) has been initiated with a 50-fs laser pulse. We show that the catalytic mechanism, involving proton and hydride transfers, proceeds with time constants of 3 ps and 400 ps. It is known that catalysis by POR involves thermally excited protein dynamics; our results show that these molecular motions occur on an ultrafast timescale.*Note: The version of this paper initially published online was incorrectly labeled as an 'Article'; the correct category should be 'Brief Communication'. We apologize for any inconvenience this may have caused. This mistake has been corrected in the HTML and print version of the paper.