Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report
Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report
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DOI：
10.1186/s12936-016-1527-8
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发表时间：
2016-09-17
期刊：
影响因子：
3
通讯作者：
Viebig, Nicola K.
中科院分区：
文献类型：
--
作者：
Chene, Arnaud;Houard, Sophie;Viebig, Nicola K.
由恶性疟原虫感染引起的胎盘性疟疾是一个主要的健康问题，表现为母亲的严重疾病和贫血、胎儿发育受损、出生体重低或自然流产。目前，预防胎盘疟疾有赖于两项因耐药性传播而失效的关键战略：长效驱虫蚊帐和孕期间歇预防性治疗。胎盘型疟疾疫苗将是现有控制工具的一个有吸引力的、具有成本效益的补充。两种胎盘型疟疾候选疫苗目前处于Ia/b期临床试验。在欧洲疫苗倡议主办的两次讲习班上，一次是2014年4月在巴黎，另一次是2014年11月在布鲁塞尔，胎盘疟疾疫苗研究的主要行为者讨论了协调临床开发计划和免疫分析的问题，目的是确定标准，以便能够对不同的胎盘疟疾候选疫苗进行比较评估。这些研讨会的建议应指导研究人员和临床医生进一步开发胎盘型疟疾疫苗。
Placental malaria caused by Plasmodium falciparum infection constitutes a major health problem manifesting as severe disease and anaemia in the mother, impaired fetal development, low birth weight or spontaneous abortion. Prevention of placental malaria currently relies on two key strategies that are losing efficacy due to spread of resistance: long-lasting insecticide-treated nets and intermittent preventive treatment during pregnancy. A placental malaria vaccine would be an attractive, cost-effective complement to the existing control tools. Two placental malaria vaccine candidates are currently in Phase Ia/b clinical trials. During two workshops hosted by the European Vaccine Initiative, one in Paris in April 2014 and the other in Brussels in November 2014, the main actors in placental malaria vaccine research discussed the harmonization of clinical development plans and of the immunoassays with a goal to define standards that will allow comparative assessment of different placental malaria vaccine candidates. The recommendations of these workshops should guide researchers and clinicians in the further development of placental malaria vaccines.