TRANSIT OF PHARMACEUTICAL DOSAGE FORMS THROUGH THE SMALL-INTESTINE
TRANSIT OF PHARMACEUTICAL DOSAGE FORMS THROUGH THE SMALL-INTESTINE
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DOI：
10.1136/gut.27.8.886
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发表时间：
1986-08-01
期刊：
影响因子：
24.5
通讯作者：
FARA, JW
中科院分区：
文献类型：
--
作者：
DAVIS, SS;HARDY, JG;FARA, JW
201 项研究已使用伽马闪烁扫描技术对正常受试者进行了药物剂型胃肠道转运的测量。溶液、小颗粒和单一单位（骨架片和渗透泵）与胃中不同量的食物一起给药，从禁食状态到丰盛的早餐。胃排空受到剂型性质和胃中食物存在的影响。即使胃处于消化模式，溶液和颗粒也会被清空，而单个单位会保留很长一段时间，具体取决于膳食的大小。相反，测量的肠道通过时间与剂型和进食状态无关。约三小时的小肠通过时间（平均±1小时SEM）对于药物在胃肠道特定位置持续释放的剂型设计具有影响。
The gastrointestinal transit of pharmaceutical dosage forms has been measured in 201 studies in normal subjects using gamma scintigraphy. Solutions, small pellets, and single units (matrix tablets and osmotic pumps) were administered with different amounts of food in the stomach, ranging from fasted state to heavy breakfast. Gastric emptying was affected by the nature of the dosage form and the presence of food in the stomach. Solutions and pellets were emptied even when the stomach was in the digestive mode, while single units were retained for long periods of time, depending on the size of the meal. In contrast, measured intestinal transit times were independent of the dosage form and fed state. The small intestinal transit time of about three hours (mean .+-. 1 h SEM) has implications for the design of dosage forms for the sustained release of drugs in specific positions in the gastrointestinal tract.