Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence
Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence
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DOI：
10.1073/pnas.0609265103
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发表时间：
2006-12-12
影响因子：
11.1
通讯作者：
Weisman, R. Bruce
中科院分区：
文献类型：
--
作者：
Cherukuri, Paul;Gannon, Christopher J.;Weisman, R. Bruce
个性化的、化学上纯净的单壁碳纳米管已经被静脉注射到兔子身上，并通过它们特有的近红外荧光进行监测。光谱显示，血液蛋白在几秒钟内取代了合成表面活性分子的纳米管涂层。血清中纳米管浓度呈指数下降，半衰期为1.0+/-0.1h。从行为学和病理学检查均未检测到低水平纳米管暴露的不良影响。静脉注射后24小时。给药后，只在肝脏中发现了显著浓度的纳米管。这些结果表明，脱束的单壁碳纳米管是高对比度的近红外荧光团，可以使用光学方法在哺乳动物组织中灵敏和选择性地进行跟踪。此外，无急性毒性和有希望的循环持久性暗示了碳纳米管在未来的药物应用中的潜力。
Individualized, chemically pristine single-walled carbon nanotubes have been intravenously administered to rabbits and monitored through their characteristic near-infrared fluorescence. Spectra indicated that blood proteins displaced the nanotube coating of synthetic surfactant molecules within seconds. The nanotube concentration in the blood serum decreased exponentially with a half-life of 1.0 +/- 0.1 h. No adverse effects from low-level nanotube exposure could be detected from behavior or pathological examination. At 24 h after i.v. administration, significant concentrations of nanotubes were found only in the liver. These results demonstrate that debundled single-walled carbon nanotubes are high-contrast near-infrared fluorophores that can be sensitively and selectively tracked in mammalian tissues using optical methods. In addition, the absence of acute toxicity and promising circulation persistence suggest the potential of carbon nanotubes in future pharmaceutical applications.