Hydration biomarkers in free-living adults with different levels of habitual fluid consumption.
Hydration biomarkers in free-living adults with different levels of habitual fluid consumption.
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DOI：
10.1017/s0007114512003601
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发表时间：
2013-05
影响因子：
3.6
通讯作者：
Tack, Ivan
中科院分区：
文献类型：
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作者：
Perrier, Erica;Vergne, Sebastien;Klein, Alexis;Poupin, Marie;Rondeau, Pascale;Le Bellego, Laurent;Armstrong, Lawrence E;Lang, Florian;Stookey, Jodi;Tack, Ivan
关于习惯性液体摄入对生理的影响知之甚少。具体而言，在日常条件下消耗不同液体体积的成年人中，没有长时间运动或环境暴露，尚未充分探索水合状态和身体水分调节的生物标志物。本研究的目的是比较习惯性不同液体摄入量的成年人在评估水合状态、调节全身水分和肾脏病理风险方面的生物标志物。在本横断面研究中，71名成年人（32名男性，39名女性，年龄25-40岁）根据每日液体摄入量进行分类：39名低饮酒者（LD; ≤ 1.2升/d）和32名高饮酒者（HD; 2-4升/d）。在连续4天内，评估了尿液参数（第1天的第一次晨尿（FMU）和随后的24小时尿液（24 hU）采集）、血液参数以及食物和饮料摄入量。方差分析和非参数比较显示LD组和HD组在24 hU体积方面存在显著差异（1·0（se 0·1）v. 2·4（se 0·1）升），比重（中位数1.023 v.1.010）、渗透压（767（se 27）v.371（se 33）mOsm/kg）和颜色（3.1（se 0.2）v.1.8（se 0.2））。同样，在FMU中，LD组产生更少量的更浓缩的尿液。血浆皮质醇，肌酐和精氨酸加压素浓度显着较高的LD。两组之间的血浆渗透压相似，表明尽管液体摄入量较低，但生理适应仍能保持血浆渗透压。必须检查维持血浆渗透压的适应性的长期影响，特别是在肾脏健康的背景下。
Little is known about the impact of habitual fluid intake on physiology. Specifically, biomarkers of hydration status and body water regulation have not been adequately explored in adults who consume different fluid volumes in everyday conditions, without prolonged exercise or environmental exposure. The purpose of the present study was to compare adults with habitually different fluid intakes with respect to biomarkers implicated in the assessment of hydration status, the regulation of total body water and the risk of kidney pathologies. In the present cross-sectional study, seventy-one adults (thirty-two men, thirty-nine women, age 25–40 years) were classified according to daily fluid intake: thirty-nine low drinkers (LD; ≤ 1·2 litres/d) and thirty-two high drinkers (HD; 2–4 litres/d). During four consecutive days, urinary parameters (first morning urine (FMU) on day 1 and subsequent 24 h urine (24hU) collections), blood parameters, and food and beverage intake were assessed. ANOVA and non-parametric comparisons revealed significant differences between the LD and HD groups in 24hU volume (1·0 (se 0·1) v. 2·4 (se 0·1) litres), specific gravity (median 1·023 v. 1·010), osmolality (767 (se 27) v. 371 (se 33) mOsm/kg) and colour (3·1 (se 0·2) v. 1·8 (se 0·2)). Similarly, in the FMU, the LD group produced a smaller amount of more concentrated urine. Plasma cortisol, creatinine and arginine vasopressin concentrations were significantly higher among the LD. Plasma osmolality was similar between the groups, suggesting physiological adaptations to preserve plasma osmolality despite low fluid intake. The long-term impact of adaptations to preserve plasma osmolality must be examined, particularly in the context of renal health.