Circadian behavior of P-wave duration, P-wave area, and PR interval in healthy subjects
Circadian behavior of P-wave duration, P-wave area, and PR interval in healthy subjects
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DOI：
10.1111/j.1542-474x.2001.tb00092.x
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发表时间：
2001-04-01
影响因子：
1.9
通讯作者：
Malik, M
中科院分区：
文献类型：
--
作者：
Dilaveris, PE;Färbom, P;Malik, M
背景：P 波持续时间的延长早已被证明表明存在房颤的高风险。之前未测试过 P 波特征的昼夜变化及其对心率变化的动态适应。方法：为了评估 P 波持续时间、P 面积和 PR 间期的昼夜模式及其与 RR 间期的线性拟合关系，50 名健康志愿者（25 名男性，平均年龄 34 +/- 10 岁）使用数字 12 导联动态心电图记录仪进行了 24 小时动态心电图 (ECG) 记录。中位 P 波持续时间、P 面积和 PR 间期是根据每个 10 秒心电图记录构建的平均 12 导联心电图来计算的。进行单次谐波回归分析以揭示上述心电图参数是否存在昼夜节律变化。结果：P面积（P < 0.0001，R-2 = 0.78）、PR间期（P < 0.0001，R-2 = 0.92）、P面积/RR斜率（P < 0.0001，R-2 = 0.55）和PR/RR斜率（P < 0.0001，R-2 = 0.55） 0.0001，R-2 = 0.42）显示出高度显着的昼夜变化，而 P 波持续时间（P = 0.016，R-2 = 0.32）和 P 持续时间 / RR 斜率（P = 0.011，R-2 = 0.18）的周期性性质仅通过谐波回归分析表明。结论：P 波持续时间、P 面积和 PR 间期在健康人群中表现出显着的昼夜变化。科目。 P 面积/RR、PR/RR 和 P 持续时间/RR 之间的关系也表现出显着的昼夜模式。
Background: The prolongation of P-wave duration has long been shown to indicate the presence of high risk for atrial fibrillation. The circadian variation of P-wave characteristics and their dynamic adaptation to heart rate changes was not tested before.Methods: To evaluate the diurnal pattern of P-wave duration, P area, and PR interval and of their linearly fitted relation with RR interval, 50 healthy volunteers (25 men, mean age 34 +/- 10 years) underwent 24-hour ambulatory electrocardiographic (ECG) recording with digital 12-lead Holter recorders. The median P-wave duration, P area, and PR interval were calculated from the average 12-lead ECG constructed from each 10-second ECG recording. Single harmonic regression analysis was performed to reveal the presence of circadian variation in the aforementioned ECG parameters.Results: The P area (P < 0.0001, R-2 = 0.78), the PR interval (P < 0.0001, R-2 = 0.92), the P area / RR slope (P < 0.0001, R-2 = 0.55), and the PR/RR slope (P < 0.0001, R-2 = 0.42) showed a highly significant circadian variation while the periodic nature of P-wave duration (P = 0.016, R-2 = 0.32) and of the P duration / RR slope (P = 0.011, R-2 = 0.18) was only indicated by harmonic regression analysis.Conclusions: P-wave duration, P area, and PR interval show a significant circadian variation in healthy subjects. The relations between P area/RR, PR/RR, and P duration/RR also demonstrate a significant diurnal pattern.