Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses.
Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses.
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DOI：
10.1158/1055-9965.epi-17-0081
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发表时间：
2017-08
期刊：
影响因子：
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通讯作者：
Ludwig-McGill Cohort Study
中科院分区：
文献类型：
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作者：
Sichero L;El-Zein M;Nunes EM;Ferreira S;Franco EL;Villa LL;Ludwig-McGill Cohort Study
α-人乳头瘤病毒（α-HPV）在宫颈癌中起因果作用，但对生殖器β - hpv感染的流行病学知之甚少。我们使用Luminex和聚合酶链反应（PCR）杂交技术检测了参加路德维希-麦吉尔队列研究的505名妇女的宫颈样本在入组时和12个月随访时的β-和α- hpv患病率。我们比较了β-和α- hpv的流行病学相关性，并比较了这两种类型的基因型之间的共发性和与宫颈细胞学异常的相关性。在两次就诊时，β-HPV型感染比α-HPV型感染更普遍（累计患病率分别为27.3%和21.6%，P=0.034）。然而，β- hpv大多是短暂的，只有1.98%的女性在12个月时保持原来的阳性，而α- hpv的持久性更高（5.15%）（P = 0.007）。年龄、胎次和性活动变量是α-HPV的预测因子，而不是β-HPV的预测因子。α-型和β-型分别独立发生。宫颈异常的风险增加仅限于感染α-9或α-6型HPV的妇女。我们没有发现β-HPV感染的流行病学相关性。在子宫颈检测到β-HPV类型往往是随机和短暂的发作，不能通过α- hpv感染特征的性传播相关性来解释。虽然β-人乳头状瘤病毒可能起直接或间接的致癌作用是合理的，但缺乏对这些病毒检测发作的流行病学相关性以及与宫颈病变的相关性，不利于它们作为性传播媒介在宫颈癌发生中的辅助作用。
Alpha-human papillomavirus (α-HPV) play a causal role in cervical cancer but little is known about the epidemiology of genital Beta-HPV infection. We used Luminex and polymerase chain reaction (PCR) hybridization to detect β- and α-HPVs prevalence at enrolment and 12-months follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiological correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytological abnormalities. Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P=0.034). β-HPVs were mostly transient, however, only 1.98% women retained their original positivity at 12 months, whereas, persistence was higher for α-HPVs (5.15%) (P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with α-9 or α-6 HPV types. We found no epidemiological correlates for β-HPV infections. Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role the lack of epidemiological correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis.