Antithrombotic Activities of Luteolin In Vitro and In Vivo
Antithrombotic Activities of Luteolin In Vitro and In Vivo
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DOI：
10.1002/jbt.21726
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发表时间：
2015-12-01
影响因子：
3.6
通讯作者：
Kim, Seung
中科院分区：
文献类型：
--
作者：
Choi, Jun-Hui;Kim, Yoon-Sik;Kim, Seung
本研究的目的是探讨毛地黄黄酮是否影响促凝血蛋白酶的活性和纤维蛋白凝块的形成，并影响血栓形成和凝血在Sprague-Dawle大鼠。木犀草素对凝血酶和FXa活性的抑制率分别为29.1%和16.2%。木犀草素也抑制纤维蛋白聚合物的形成在浊度和显微镜分析使用荧光共轭物。凝血试验发现木樨草素延长活化部分凝血活酶时间和凝血酶原时间。此外，毛地黄黄酮保护氧化应激诱导的血栓形成的发展，在氯化铁诱导的颈动脉血栓模型。这项研究表明，毛地黄黄酮可能通过减少或预防血栓形成挑战而有用，并且可以帮助我们更好地了解毛地黄黄酮的抗血栓形成作用。(C)2015 Wiley Periodicals，Inc.
The objectives of present study were to investigate whether luteolin affects procoagulant proteinase activity and fibrin clot formation and influences thrombosis and coagulation in Sprague-Dawle rats. Luteolin significantly inhibited the enzymatic activity of thrombin and FXa activity by 29.1% and 16.2%. Luteolin also inhibited fibrin polymer formation in turbidity and microscopic analysis using fluorescent conjugate. Coagulation assay of luteolin was found to prolong activated partial thromboplastin time and prothrombin time. Moreover, luteolin protected the development of oxidative stress induced thrombosis in the FeCl3-induced carotid arterial thrombus model. This study demonstrated that luteolin may be useful by reducing or preventing thrombotic challenge and can help us better understand the antithrombotic action of luteolin. (C) 2015 Wiley Periodicals, Inc.