Lower maternal serum 25(OH) D in first trimester associated with higher autism risk in Chinese offspring
Lower maternal serum 25(OH) D in first trimester associated with higher autism risk in Chinese offspring
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DOI：
10.1016/j.jpsychores.2016.08.013
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发表时间：
2016-10-01
影响因子：
4.7
通讯作者：
Xiao, Huajun
中科院分区：
文献类型：
--
作者：
Chen, Jianzhang;Xin, Kuolin;Xiao, Huajun
目的：本研究的目的是探讨母亲血清维生素D水平在孕早期和ASD的风险之间的关联在3-7岁的office.Methods：采用病例对照设计，68名儿童诊断为ASD和68名性别和年龄匹配的典型发育的儿童。这些参与者的存档母体血液样本来自妊娠前三个月（胎龄1113周）。从这些样本中测量母体血清25羟维生素D3 [25（OH）D]、未代谢叶酸（FA）、维生素B12、同型半胱氨酸（HCY）和高敏C反应蛋白（CRP）水平。结果：自闭症组母亲血清25（OH）D水平显著低于正常发育组[19.2（IQR：15.8-22.9）ng/ml vs. 24.3（193-27.3）ng/ml，P < 0.0011，维生素D缺乏率分别为55.9%和29.4%（P < 0.001）。25（OH）D水平随汽车评分的严重程度降低而升高（r = 0.302，P < 0.001）。孕早期孕妇血清25（OH）D水平的下三个四分位数（四分位数1、2、3）（与最高四分位数相比）与后代ASD诊断几率增加相关[OR（95%CI）Q1：1.36（0.84-2.58，P = 0.25）; Q2：2.68（1.44-4.29，P = 0.006）; Q3：3.99（2.58-7.12，P < 0.001）]。结论：孕早期母血25（OH）D水平较低与子代患自闭症的风险增加有关。如果这些发现得到证实，这可能为产前干预提供了机会，以降低ASD的风险。(C)2016 Elsevier Inc. All rights reserved.
Objective: The aim of this study was to examine the association between maternal serum vitamin D status in first trimester and risk of ASD at age 3-7 years in the offspring.Methods: Using a case-control design, 68 children diagnosed with ASD and 68 sex and age matched typically-developing children were included. Archived maternal blood samples from the first trimester of pregnancy (1113 weeks gestational age) were identified for those participants. Maternal serum levels of 25 hydroxyvitamin D3 [25(OH) D], unmetabolized folic acid (FA), vitamin B12, homocysteine (HCY) and High Sensitivity C Reactive protein (CRP) were measured from those samples. We examined the associations between those factors in pregnancy and diagnosis of ASD with logistic regression using SPSS.Results: Mothers in autistic group had significantly lower maternal serum levels of 25(OH) D than in typically-developing group [19.2(IQR: 15.8-22.9)ng/ml vs. 24.3(193-27.3)ng/ml, P < 0.0011, with 55.9% and 29.4% being vitamin D deficient, respectively (P < 0.001). Levels of 25(OH) D increased with decreasing severity of ASD as defined by the CARS score (r = 0.302, P < 0.001). Maternal first trimester serum levels of 25(OH) Din the lower 3 quartiles (quartile 1, 2, 3) (compared to the highest quartile) was associated with increased odds of ASD diagnosis in offspring [OR (95% CI) Q1: 1.36(0.84-2.58, P = 0.25); Q2: 2.68(1.44-4.29, P = 0.006); Q3:3.99(2.58-7.12, P < 0.001)].Conclusions: Lower first trimester maternal serum levels of 25(OH) D were associated with increased risk of developing autism in offspring. If these findings are confirmed, this may present an opportunity for prenatal intervention to reduce the risk for ASD. (C) 2016 Elsevier Inc. All rights reserved.