LiHMDS-Promoted Palladium-Catalyzed Sonogashira Cross-Coupling of Aryl Fluorides with Terminal Alkynes
LiHMDS-Promoted Palladium-Catalyzed Sonogashira Cross-Coupling of Aryl Fluorides with Terminal Alkynes
复制标题
DOI：
10.1021/acs.orglett.9b03815
复制
发表时间：
2019-12-06
期刊：
影响因子：
5.2
通讯作者：
Cao, Song
中科院分区：
文献类型：
--
作者：
He, Jingjing;Yang, Kang;Cao, Song
在LiHMDS存在下，发展了一种高效的Pd催化的氟代芳烃与末端炔的Sonogashira偶联反应。不活泼的富电子氟代芳烃和贫电子氟代芳烃都顺利进行，并以中等至优异的产率得到相应的内炔。
A highly efficient Pd-catalyzed Sonogashira coupling of various aryl fluorides with terminal alkynes in the presence of LiHMDS was developed. Both unreactive electron-rich fluoroarenes and electron-poor fluoroarenes proceeded smoothly and afforded the corresponding internal alkynes in moderate to excellent yields.