U-42, 126, A NEW ANTIMETABOLITE ANTIBIOTIC - PRODUCTION, BIOLOGICAL-ACTIVITY, AND TAXONOMY OF PRODUCING MICROORGANISM
U-42, 126, A NEW ANTIMETABOLITE ANTIBIOTIC - PRODUCTION, BIOLOGICAL-ACTIVITY, AND TAXONOMY OF PRODUCING MICROORGANISM
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DOI：
10.1128/aac.3.3.425
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发表时间：
1973-01-01
影响因子：
4.9
通讯作者：
DIETZ, A
中科院分区：
文献类型：
--
作者：
HANKA, LJ;DIETZ, A
通过体外筛选发现了一种新的抗代谢抗生素U-42，126。U-42，126是由Sviceus链霉菌发酵生产的。其体外抗菌活性仅限于真菌。某些细菌只有在完全合成的培养基中培养时才能被抑制。U-42，126对小鼠L1210白血病具有体内抗白血病活性。
A new antimetabolite antibiotic, U-42,126, was discovered by use of a specific in vitro screen. U-42,126 was produced by the fermentation ofStreptomyces sviceus. Its antimicrobial activity in vitro was limited to fungi. Certain bacteria were inhibited only when cultivated in completely synthetic media. U-42,126 was active in vivo against L1210 leukemia in mice.