Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice.
Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice.
复制标题
在 PGC-1α 敲除小鼠的骨骼肌中，口服亮氨酸导致的 4EBP 磷酸化受到抑制。
DOI：
10.1080/09168451.2015.1083397
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Kamei Y.
中科院分区：
文献类型：
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作者：
Yoshimura R;Minami K;Matsuda J;Sawada N;Miura S;Kamei Y.
已知亮氨酸增加mTOR介导的4 EBP磷酸化。在这项研究中，亮氨酸给予骨骼肌-PGC-1α基因敲除小鼠。我们在PGC-1α基因敲除小鼠的骨骼肌中观察到减弱的4 EBP磷酸化，但在肝脏中没有。这些数据表明，骨骼肌-PGC-1α对于亮氨酸介导的mTOR激活和蛋白质生物合成是重要的。
Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1α knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1α knockout mice. These data suggest that skeletal muscle-PGC-1α is important for leucine-mediated mTOR activation and protein biosynthesis.