Six months of high-dose xylitol in high-risk caries subjects-a 2-year randomised, clinical trial
Six months of high-dose xylitol in high-risk caries subjects-a 2-year randomised, clinical trial
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DOI：
10.1007/s00784-012-0774-5
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发表时间：
2013-04-01
影响因子：
3.4
通讯作者：
Lingstrom, Peter
中科院分区：
文献类型：
--
作者：
Campus, Guglielmo;Cagetti, Maria Grazia;Lingstrom, Peter
这项假设是，每天使用高剂量的木糖醇口香糖6个月，可以减少高危学龄儿童2年后第一磨牙表面腐烂的增量(Delta D6S)。在这项随机的临床试验中，204名有高龋齿风险的学童被分配到两个试验组，木糖醇和非木糖醇组。2年后，74名接受木糖醇治疗的学龄儿童和83名非接受木糖醇治疗的学龄儿童重新评估了龋齿状况、唾液变形链球菌和乳杆菌。使用非参数Mann-Whitney U检验评估基线时和随访时登记的组之间平均匕首D6S的差异。结果是在永久第一磨牙中发生了可检测到的初期(D-1-D-2)和显性(D-3)龋损。在木糖醇组，儿童第一恒磨牙龋坏的比例在基线和随访期分别为1.43%和2.86%，而非木糖醇组分别为10.26%和16.66%(p<；0.01)。在非木糖醇组的平均值上也观察到了统计学上的显著差异：显性病变的D6S为0.18(P=0.03)，初始病变的D6S为0.67(P=0.02)。使用含有高剂量木糖醇的口香糖6个月被证明对高危儿童的龋病发展有长期影响。基于6个月通过口香糖给予高剂量木糖醇的学校预防计划被证明在控制高危儿童的龋齿增长方面是有效的。
The hypothesis was that the daily use of a high dose of a xylitol chewing gum for 6 months would reduce the increment of decayed permanent first molar surfaces (Delta D6S) in high-risk schoolchildren after 2 years.In this randomised, clinical trial, 204 schoolchildren with a high caries risk were assigned to two experimental groups, xylitol and non-xylitol. Caries status, salivary mutans streptococci, and lactobacilli were re-evaluated 2 years later in 74 xylitol-treated and 83 non-xylitol-treated schoolchildren. Differences in mean a dagger D6S between groups registered at baseline and at follow-up were evaluated using the nonparametric Mann-Whitney U test.Outcome was the development of detectable carious lesions initial (D-1-D-2) and manifest (D-3) in the permanent first molars. In the xylitol group, the difference in proportion of children with decayed first permanent molars at baseline and follow-up was 1.43 % for manifest lesion and 2.86 % for initial lesions; while in the non-xylitol group was 10.26 % (p < 0.01) and 16.66 % (p < 0.01), respectively. A statistically significant difference regarding means was also observed in the non-xylitol group: the a dagger D6S for manifest lesion was 0.18 (p = 0.03) and 0.67 (p = 0.02) for initial lesion.The use of a chewing gum containing a high dose of xylitol for a period of 6 months has been shown to produce a long-term effect on caries development in high caries-risk children.A school-based preventive programme based on 6 months' administration of a high dose of xylitol via chewing gum proved to be efficacious in controlling caries increment in high-risk children.