FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
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DOI：
10.5483/bmbrep.2015.48.6.031
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发表时间：
2015-06
期刊：
影响因子：
3.8
通讯作者：
Kim Yoon S
中科院分区：
文献类型：
--
作者：
Kim BK;Yoo HI;Kim I;Park J;Kim Yoon S
结直肠癌（CRC）是世界上第三大常见癌症，也是癌症相关发病率和死亡率最高的癌症。WNT信号传导通过WNT与各种受体（包括卷曲蛋白（FZD））结合而启动，并且通过调节增殖、分化、迁移、凋亡和极性在CRC和其他肿瘤发展中起关键作用。在FZD家族的成员中，FZD 6在各种组织中广泛表达，并且已经在几种癌症中报道了其过表达，表明在癌症发展中的重要作用。在这项研究中，我们研究了FZD 6在CRC患者中的表达，发现与配对的相邻非肿瘤组织相比，FZD 6在肿瘤中的表达增加。此外，我们发现FZD 6的表达在CRC细胞中受到miR 199 a5 p的负调控。这些结果表明，由miR-199 a-5 p表达减少介导的FZD 6过表达可能在CRC的发展中起重要作用。[BMB报告2015; 48（6）：360-366]
Colorectal cancer (CRC), the third most common cancer worldwide, also has the highest rate of cancer-related morbidity and mortality. WNT signaling is initiated by binding of WNT to various receptors, including frizzleds (FZDs), and plays a critical role in CRC and other tumor development by regulating proliferation, differentiation, migration, apoptosis, and polarity. Among the members of the FZD family, FZD6 is broadly expressed in various tissues, and its overexpression has been reported in several cancers, suggesting an important role in cancer development. In this study, we investigated the expression of FZD6 in patients with CRC and found it to be increased in tumors, as compared to paired adjacent non-tumor tissues. Additionally, we found that FZD6 expression was negatively regulated by miR199a5p in CRC cells. These results suggest that overexpression of FZD6, mediated by reduced expression of miR-199a-5p, may play an important role in the development of CRC. [BMB Reports 2015; 48(6): 360-366]