ANTIBACTERIAL AND MOLLUSCICIDAL PHENOLIC-ACIDS FROM SPONDIAS MOMBIN
ANTIBACTERIAL AND MOLLUSCICIDAL PHENOLIC-ACIDS FROM SPONDIAS MOMBIN
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DOI：
10.1055/s-2006-959532
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发表时间：
1994-10-01
期刊：
影响因子：
2.7
通讯作者：
VLIETINCK, A
中科院分区：
文献类型：
--
作者：
CORTHOUT, J;PIETERS, L;VLIETINCK, A
由于其抗菌特性，在传统医学中被广泛使用的绣球属植物含有一系列6-烯基水杨酸。采用层析相结合的方法，从海棘叶和海棘茎的乙醇提取物中分离得到这两种化合物。经核磁共振和质谱鉴定，它们的结构分别为（17:3）、（17:2）和（17:1）pelandjuaic acid[或6-（8'Z,11'Z,14' z -庚十烯基）-水杨酸，6-（8'Z,11'Z-庚十烯基）-水杨酸，6-（10' z -庚十烯基）-水杨酸]，6-（12' z -十二烯基）-水杨酸，6-（15' z -庚二十烯基）-水杨酸，后两个化合物为新化合物。这些酚酸对蜡样芽孢杆菌、化脓性链球菌和fortuitum分枝杆菌具有明显的抗菌作用（最低杀菌浓度范围为3-25 μ g/ml），并对血吸虫生命周期中的中间宿主——光螺（Biomphalaria glabrata）具有杀螺作用。由于其高杀螺活性（LC（90）低至1-3 ppm），这些长链水杨酸衍生物可能是预防血吸虫病的重要工具。
Spondias mombin L. (Anacardiaceae), used in traditional medicine because of its antimicrobial properties, was found to contain a series of 6-alkenylsalicylic acids. They were isolated from the ethanolic extract of leaves and stems of Spondias mombin by a combination of chromatographic methods. Their structure was determined by NMR and MS techniques as (17:3), (17:2) and (17:1) pelandjuaic acid [or 6-(8'Z,11'Z,14'Z-heptadecatrienyl)-salicyl acid, 6-(8'Z,11'Z-heptadecadienyl)-salicylic acid, and 6-(10'Z-heptadecenyl)-salicylic acid, respectively], 6-(12'Z-nonadecenyl)-salicylic acid, and 6-(15'Z-heneicosenyl)-salicylic acid, the two last compounds being new ones. These phenolic acids were shown to have a pronounced antibacterial effect against Bacillus cereus, Streptococcus pyogenes, and Mycobacterium fortuitum (minimal bactericidal concentration in a concentration range of 3-25 mu g/ml), and a molluscicidal effect against the snail Biomphalaria glabrata, an intermediate host in the schistosome life cycle. Because of their high molluscicidal activity (LC(90) down to 1-3 ppm), these long-chain salicylic acid derivatives may be important tools in the prevention of schistosomiasis.