MEASUREMENT OF IRON STORES USING DEFEROXAMINE
MEASUREMENT OF IRON STORES USING DEFEROXAMINE
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DOI：
10.7326/0003-4819-68-3-518
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发表时间：
1968-01-01
影响因子：
39.2
通讯作者：
TAYLOR, FH
中科院分区：
文献类型：
--
作者：
BALCERZAK, SP;WESTERMAN, MP;TAYLOR, FH
评价去铁胺（DFO）诱导的尿铁排泄，作为测量铁储存的试验。通过静脉切开术和组织学技术或仅通过组织学方法评估铁储存。DFO引起的铁尿症与静脉血铁动员量呈线性相关。DFO后尿铁排泄量大于2200 [mu]g/24小时表明铁过量的可能性很高。DFO后，铁尿低于600 [mu]g/24小时常提示铁缺乏。大多数铁储备正常的受试者介于这两个极端之间。然而，一些研究结果表明，DFO后尿中排出的铁量并不完全与铁储存量有关。用静脉切开法测定了11名正常人的铁贮量，平均为687 mg，范围为130 ~ 1900 mg。
Deferoxamine (DFO)-induced urinary Fe excretion was evaluated as a test for the measurement of Fe stores. Iron stores were assessed both by phlebotomy and histologic techniques or by histologic methods alone. A close linear correlation was found between DFO-provoked sideruria and Fe mobil-izable by phlebotomy. Post-DFO urinary Fe excretion greater than 2200 [mu]g/24 hr. indicated Fe excess with a high degree of probability. After DFO, sideruria less than 600 [mu]g/24 hr. frequently signaled Fe deficiency. Most subjects with normal Fe stores fell between these 2 extremes. Several findings, however, indicated that the amount of Fe excreted in urine after DFO was not related entirely to Fe store size. The Fe stores of 11 normal men were measured by phlebotomy and were found to average 687 mg with a range of 130 to 1900 mg.