Conserved Functional Connectivity but Impaired Effective Connectivity of Thalamocortical Circuitry in Schizophrenia
Conserved Functional Connectivity but Impaired Effective Connectivity of Thalamocortical Circuitry in Schizophrenia
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DOI：
10.1089/brain.2012.0100
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发表时间：
2012-12-01
影响因子：
3.4
通讯作者：
Postle, Bradley R.
中科院分区：
文献类型：
--
作者：
Guller, Yelena;Tononi, Giulio;Postle, Bradley R.
精神分裂症是一种严重的精神疾病，其神经生物学基础仍然难以捉摸。一种假说强调丘脑功能紊乱。我们以前使用的同时单脉冲经颅磁刺激（spTMS）和功能磁共振成像（fMRI）显示，精神分裂症患者的丘脑有一个减少的spTMS诱发的反应，丘脑和丘脑和上级额回之间的有效连接减少。为了更好地理解可能伴随或解释这些发现的因素，我们在相同的参与者中调查了静息状态功能连接、白色物质结构连接和灰质完整性。精神分裂症患者与健康对照组在静息状态下的功能或白色物质结构连接性没有差异，尽管他们确实显示了灰质完整性的降低。然而，在这个区域，spTMS诱发的反应没有组间差异。在丘脑的一个区域，也有灰质强度异常，虽然不是在一个水平，幸存的多重比较校正，spTMS诱发的反应在患者是有缺陷的。这些结果表明，结构和功能的措施不一定是互补的。此外，鉴于其识别缺陷的敏感性与传统的成像方法不明显，这些结果突出了实用的spTMS-fMRI，一种方法，直接和因果探测有效的连接，作为一种工具，用于研究脑为基础的疾病。
Schizophrenia is a severe mental illness with neurobiological bases that remain elusive. One hypothesis emphasizes disordered thalamic function. We previously used concurrent single pulse transcranial magnetic stimulation (spTMS) and functional magnetic resonance imaging (fMRI) to show that individuals with schizophrenia have a decreased spTMS-evoked response in the thalamus, and decreased effective connectivity between thalamus and insula and thalamus and superior frontal gyrus. To better understand the factors that may accompany or account for these findings, we investigated, in the same participants, resting state functional connectivity, white matter structural connectivity, and grey matter integrity. Patients with schizophrenia did not differ from healthy control subjects in resting state functional-or white matter structural connectivity, although they did show decreased measures of grey matter integrity in the insula. However, in this region, the spTMS-evoked response did not differ between groups. In a region of the thalamus that also had grey matter intensity abnormalities, although not at a level that survived correction for multiple comparisons, the spTMS-evoked response in patients was deficient. These results suggest that measures of structure and function are not necessarily complementary. Further, given its sensitivity for identifying deficits not evident with traditional imaging methods, these results highlight the utility of spTMS-fMRI, a method that directly and causally probes effective connectivity, as a tool for studying brain-based disorders.