Rapid detection of Cu2+ by a paper-based microfluidic device coated with bovine serum albumin (BSA)-Au nanoclusters
Rapid detection of Cu2+ by a paper-based microfluidic device coated with bovine serum albumin (BSA)-Au nanoclusters
复制标题
通过涂有牛血清白蛋白（BSA）-Au纳米团簇的纸基微流控装置快速检测Cu2+
DOI：
10.1039/c5an01016k
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发表时间：
2015-01-01
期刊：
影响因子：
4.2
通讯作者：
Kong, Jilie
中科院分区：
文献类型：
--
作者：
Fang, Xueen;Zhao, Qianqian;Kong, Jilie
在这项工作中，牛血清白蛋白（BSA）-Au纳米团簇被用来涂覆纸基微流控器件。该装置充当Cu 2+生物传感器，其在检测铜离子时显示荧光猝灭。该传感器的检测限可以通过改变装置的吸水能力来调节。定性和半定量结果可以在不借助任何先进仪器的情况下直观地获得。该传感器可以快速检测Cu 2+，具有较高的特异性和灵敏度，这将是有用的床旁检测（POCT）。
In this work, bovine serum albumin (BSA)-Au nanoclusters were used to coat a paper-based microfluidic device. This device acted as a Cu2+ biosensor that showed fluorescence quenching on detection of copper ions. The detection limit of this sensor could be adjusted by altering the water absorbing capacity of the device. Qualitative and semi-quantitative results could be obtained visually without the aid of any advanced instruments. This sensor could test Cu2+ rapidly with high specificity and sensitivity, which would be useful for point-of-care testing (POCT).