Organoselenium Small Molecules and Chromium(III) Complexes for Intervention in Chronic Low-grade Inflammation and Type 2 Diabetes.
Organoselenium Small Molecules and Chromium(III) Complexes for Intervention in Chronic Low-grade Inflammation and Type 2 Diabetes.
复制标题
有机硒小分子和铬 (III) 复合物用于干预慢性低度炎症和 2 型糖尿病。
DOI：
10.2174/1568026615666150827094815
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发表时间：
2015
影响因子：
3.4
通讯作者：
Kaixun Huang
中科院分区：
文献类型：
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作者：
Jun Zhou;Huibi Xu;Kaixun Huang
越来越多的证据表明，慢性低度炎症发生在腹部肥胖、胰岛素抵抗、2型糖尿病及相关并发症中，促炎细胞因子在2型糖尿病的发生和发展中起重要作用。因此，这些发现为使用抗炎策略纠正代谢紊乱提供了新的机会。新的合成生物活性小分子干扰慢性、低度炎症和2型糖尿病的发现引起了药物化学领域的广泛关注。迄今为止，许多有机硒小分子和铬（III）配合物已被证明具有缓解慢性低度炎症和2型糖尿病的潜力，包括依布硒、硒代蛋氨酸、吡啶酸铬、二代半胱氨酸铬、苯丙氨酸铬、三核丙酸铬、组氨酸铬、烟酸铬等。在此，我们综述了有机硒小分子和铬（III）复合物干预慢性低度炎症和2型糖尿病的最新进展，并讨论了它们的作用方式、潜在的分子机制和毒性。
There is growing evidence to suggest that chronic, low-grade inflammation occurs in abdominal obesity, insulin resistance, type 2 diabetes mellitus and related complications, and that proinflammatory cytokines play an important role in the onset and progression of type 2 diabetes. These findings consequently provide new opportunities for the use of anti-inflammatory strategies to correct the metabolic disorders. Discovery of new synthetic bioactive small molecules to interfere with chronic, low-grade inflammation and type 2 diabetes has attracted considerable attention in medicinal chemistry. To date, a number of organoselenium small molecules and chromium(III) complexes have been shown to have the potential to alleviate chronic low-grade inflammation and type 2 diabetes, including ebselen, selenomethionine, chromium picolinate, chromium dinicocysteinate, chromium phenylalaninate, trinuclear chromium propionate, chromium histidinate, chromium nicotinate, etc. Here, we review recent advances in development of organoselenium small molecules and chromium(III) complexes to intervene in chronic low-grade inflammation and type 2 diabetes, and discuss their mode of action, potential molecular mechanisms and toxicity.