Linking Quorum Sensing Regulation and Biofilm Formation by Candida albicans
Linking Quorum Sensing Regulation and Biofilm Formation by Candida albicans
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DOI：
10.1007/978-1-60761-971-0_16
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发表时间：
2011-01-01
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影响因子：
--
通讯作者：
Hogan, Deborah A.
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文献类型：
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作者：
Deveau, Aurelie;Hogan, Deborah A.
白色念珠菌生物膜是由细胞外基质包围的酵母、菌丝和假菌丝细胞组成的表面相关的结构化群落，白色念珠菌生物膜通常导致危及生命的全身感染，并且由于其对抗生素法尼醇的高水平抗性而特别难以根除，法尼醇是白色念珠菌分泌的自调节分子，抑制菌丝生长和许多形态学特异性基因的表达，这些基因是稳健生物膜形成所必需的。生物膜发育的许多阶段受到法尼醇的影响，包括细胞对基质的粘附，成熟生物膜的结构，由于这些原因，了解法尼醇的作用机制可能有助于开发针对白色念珠菌生物膜细胞的新的抗真菌化合物，可能使生物膜对抗生素更敏感。
Candida albicans biofilms are surface associated, structured communities composed of yeast, hyphal, and pseudohyphal cells surrounded by in extracellular matrix C albicans biofilms often lead to life threatening systemic infections and are particularly difficult to eradicate because of their high levels of resistance to antibiotics Farnesol, in autoregulatory molecule secreted by C albicans, inhibits hyphal growth and the expression of a number of morphology specific genes that are necessary for robust biofilm formation M my stages of biofilm development ire impacted by farnesol including the adherence of cells to the substratum, the architecture of mature biofilms, and the dispersal of cells from biofilms For these reasons, understanding the mechanisms of action of farnesol could le id to the development of new antifungal compounds that target C albicans biofilm cells, perhaps rendering biofilms more sensitive to antibiotics Here, we describe several methods for the analysis of the effects of farnesol on biofilm formation and function