Identification of cognitive impairment in the elderly: Homocysteine is an early marker
Identification of cognitive impairment in the elderly: Homocysteine is an early marker
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DOI：
10.1159/000017092
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发表时间：
1999-01-01
影响因子：
2.4
通讯作者：
Regland, B
中科院分区：
文献类型：
--
作者：
Lehmann, M;Gottfries, CG;Regland, B
在336名连续患者参加了大学附属的记忆单位，临床和心理的结果，神经影像学和实验室检查进行了分析。早期Alzheimer病占3%，老年性痴呆（SDAT）占16%，血管性痴呆（VAD）占20%，其他痴呆占9%，轻度认知障碍（dysmentia）占32%，主观症状仅占21%。血管危险因素，血清同型半胱氨酸，载脂蛋白E4负荷和神经影像病理学的增加被发现在痴呆，但也在精神障碍和主观症状的患者。同型半胱氨酸水平与认知能力呈负相关。血清同型半胱氨酸的增加，这是病理性的VAD，Dysmentia和SDAT，可能是一个干扰的大脑一碳代谢和信号加速发展的认知疾病的指示。
In 336 consecutive patients attending a university-affiliated memory unit, clinical and psychological findings, neuroimaging and laboratory tests were analyzed. The patients were diagnosed with early Alzheimer's disease 3%, senile dementia (SDAT) 16%, vascular dementia (VAD) 20%, other dementias 9%, minor cognitive impairment (dysmentia) 32% and subjective symptoms only 21%. Increases in vascular risk factors, serum homocysteine, ApoE4 load and neuroimaging pathology were found in dementia but also in dysmentia and in patients with subjective symptoms only. The homocysteine levels correlated inversely with cognitive performance. The increases in serum homocysteine, which were pathological in VAD, Dysmentia and SDAT, may be indicative of a disturbed cerebral one-carbon metabolism and signal-accelerated development of cognitive disease.