A retrospective analysis of bronchiectasis in patients with aspirin-exacerbated respiratory disease.

A retrospective analysis of bronchiectasis in patients with aspirin-exacerbated respiratory disease.
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阿司匹林加重呼吸道疾病患者支气管扩张的回顾性分析。

DOI:
10.1016/j.jaip.2020.04.017
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发表时间:
2020
期刊:
The journal of allergy and clinical immunology. In practice
影响因子:
--
通讯作者:
Buchheit,KathleenM
Buchheit,KathleenM
中科院分区:
--
文献类型:
--
作者:
Chen,Yih-ChiehS;Bensko,JillianC;Laidlaw,TanyaM;Buchheit,KathleenM

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Risk factors for bronchiectasis include airway obstruction, cystic fibrosis, immune deficiency, recurrent pulmonary infections, cigarette smoking, allergic bronchopulmonary aspergillosis (ABPA), atopy, and other systemic inflammatory diseases1, 2, 3. Bronchiectasis is associated with severe asthma and is believed to be a contributor to asthma severity. Coman et al. reported that bronchiectasis may be identified by chest CT in up to 47% of patients with severe asthma, and that patients with severe asthma and bronchiectasis were more likely (odds ratio= 2.24) to have hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) 4. However, the relationship between bronchiectasis and aspirin-exacerbated respiratory disease (AERD), the triad of adult-onset asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and pathognomonic respiratory reactions to NSAIDs that inhibit cyclooxygenase 1, is not known.Bronchiectasis is also associated with chronic rhinosinusitis (CRS). In a Spanish cohort, 80% of the patients with bronchiectasis were also diagnosed with CRS, and 26% were diagnosed with CRSwNP5. In a United States cohort, CRS was present in 45% of patients with bronchiectasis, and the presence of both CRS and bronchiectasis was associated with higher rates of asthma, allergic rhinitis, gastroesophageal reflux disease (GERD), and antibody deficiency compared to patients with bronchiectasis alone6. A recent systematic
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影响因子: 3.5
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