Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology.
Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology.
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DOI：
10.1007/s13311-021-01101-x
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
La Joie R
中科院分区：
文献类型：
--
作者：
Peet BT;Spina S;Mundada N;La Joie R
额颞叶痴呆包括一组临床综合征，病理上定义为额叶和颞叶的变性。从历史上看，这些综合征的诊断具有挑战性，从症状发作到初步评估和诊断之间平均约为三年。神经影像学领域的研究揭示了各种额颞叶痴呆综合征的许多生物标志物，这为临床医生提供了缩小鉴别诊断范围并提高诊断准确性的方法。因此，神经影像学被认为是评价神经退行性疾病的核心研究工具。此外，神经退行性变的模式与额颞叶痴呆综合征的潜在神经病理学基质相关，这可以帮助临床医生确定潜在病因并改善诊断。本文综述了神经影像学的进展，并讨论了行为变异型额颞叶痴呆，语义变异型原发性进行性失语症，和非流利变异型原发性进行性失语症的表型和病理特征，如结构磁共振成像和正电子发射断层扫描。在线版本包含补充材料，可通过10.1007/s13311-021-01101-x获得。
Frontotemporal dementia encompasses a group of clinical syndromes defined pathologically by degeneration of the frontal and temporal lobes. Historically, these syndromes have been challenging to diagnose, with an average of about three years between the time of symptom onset and the initial evaluation and diagnosis. Research in the field of neuroimaging has revealed numerous biomarkers of the various frontotemporal dementia syndromes, which has provided clinicians with a method of narrowing the differential diagnosis and improving diagnostic accuracy. As such, neuroimaging is considered a core investigative tool in the evaluation of neurodegenerative disorders. Furthermore, patterns of neurodegeneration correlate with the underlying neuropathological substrates of the frontotemporal dementia syndromes, which can aid clinicians in determining the underlying etiology and improve prognostication. This review explores the advancements in neuroimaging and discusses the phenotypic and pathologic features of behavioral variant frontotemporal dementia, semantic variant primary progressive aphasia, and nonfluent variant primary progressive aphasia, as seen on structural magnetic resonance imaging and positron emission tomography. The online version contains supplementary material available at 10.1007/s13311-021-01101-x.
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DOI：
10.1136/jnnp-2017-316402
发表时间：
2018-10
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Bevan-Jones WR;Cope TE;Jones PS;Passamonti L;Hong YT;Fryer TD;Arnold R;Allinson KSJ;Coles JP;Aigbirhio FI;Patterson K;O'Brien JT;Rowe JB
通讯作者：
Rowe JB
影响因子：
14.5
作者：
Acosta-Cabronero, Julio;Patterson, Karalyn;Nestor, Peter J.
通讯作者：
Nestor, Peter J.
影响因子：
3.5
作者：
Al-Obeidi E;Al-Tahan S;Surampalli A;Goyal N;Wang AK;Hermann A;Omizo M;Smith C;Mozaffar T;Kimonis V
通讯作者：
Kimonis V
影响因子：
12.7
作者：
Ahmed, Zeshan;Bigio, Eileen H.;Kovacs, Gabor G.
通讯作者：
Kovacs, Gabor G.
影响因子：
4.2
作者：
Borghesani, V.;Battistella, G.;Gorno-Tempini, M. L.
通讯作者：
Gorno-Tempini, M. L.