Structural and metabolic changes in language areas linked to formal thought disorder
Structural and metabolic changes in language areas linked to formal thought disorder
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DOI：
10.1192/bjp.bp.107.045633
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发表时间：
2009-02-01
影响因子：
10.5
通讯作者：
Strik, Werner
中科院分区：
文献类型：
--
作者：
Horn, Helge;Federspiel, Andrea;Strik, Werner
背景语言网络在形式思维障碍的病理生理学中的作用尚未阐明。目的探讨精神分裂症形式思维障碍的特定灰质缺陷是否与左侧语言网络的静息灌注相关。方法我们使用基于体素的形态测量和磁共振成像灌注测量，研究了 13 名患有精神分裂症和不同严重程度的形式思维障碍的右利手患者和 13 名匹配的健康对照者（动脉自旋标记）。结果我们发现左额叶和左颞顶语言区的灌注与形式思维障碍的严重程度呈正相关，我们还观察到双侧灰质体积的缺陷，与颞顶区和其他大脑区域的思维障碍的严重程度呈正相关。基于体素的形态测量和动脉自旋标记测量的结果在左后颞上回和左角回重叠。结论特定灰质缺陷可能是左侧语言系统状态相关功能障碍的危险因素，导致局部过度灌注和形式思维障碍。
BackgroundThe role of the language network in the pathophysiology of formal thought disorder has yet to be elucidated.AimsTo investigate whether specific grey-matter deficits in schizophrenic formal thought disorder correlate with resting perfusion in the left-sided language network.MethodWe investigated 13 right-handed patients with schizophrenia and formal thought disorder of varying severity and 13 matched healthy controls, using voxel-based morphometry and magnetic resonance imaging perfusion measurement (arterial spin labelling).ResultsWe found positive correlations between perfusion and the severity of formal thought disorder in the left frontal and left temporoparietal language areas, We also observed bilateral deficits in grey-matter volume, positively correlated with the severity of thought disorder in temporoparietal areas and other brain regions. The results of the voxel-based morphometry and the arterial spin labelling measurements overlapped in the left posterior superior temporal gyrus and left angular gyrus.ConclusionsSpecific grey-matter deficits may be a risk factor for state-related dysfunctions of the left-sided language system, leading to local hyperperfusion and formal thought disorder.