Prognostic Significance of Focal Lesions in Whole-Body Magnetic Resonance Imaging in Patients With Asymptomatic Multiple Myeloma
Prognostic Significance of Focal Lesions in Whole-Body Magnetic Resonance Imaging in Patients With Asymptomatic Multiple Myeloma
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DOI：
10.1200/jco.2009.25.5356
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发表时间：
2010-03-20
影响因子：
45.3
通讯作者：
Goldschmidt, Hartmut
中科院分区：
文献类型：
--
作者：
Hillengass, Jens;Fechtner, Kerstin;Goldschmidt, Hartmut
目的利用全身磁共振成像（wb-MRI），几乎可以检查单克隆浆细胞病患者的整个骨髓室。脊髓MRI检测到的局灶性病变（FL）在有症状的多发性骨髓瘤（sMM）中具有预后意义。在这项研究中，我们调查了FLS在WB-MRI无症状多发性骨髓瘤（aMM）患者的预后意义。患者和MethodsWB-MRI进行了149例aMM患者。的存在和不存在的预后意义，以及数量，FL进展为sMM. ResultsFL是存在于28%的患者。FL本身的存在和多于一个FL的数量是进展为sMM的最强不良预后因素（P
PurposeWith whole-body magnetic resonance imaging (wb-MRI), almost the whole bone marrow compartment can be examined in patients with monoclonal plasma cell disease. Focal lesions (FLs) detected by spinal MRI have been of prognostic significance in symptomatic multiple myeloma (sMM). In this study, we investigated the prognostic significance of FLs in wb-MRI in patients with asymptomatic multiple myeloma (aMM).Patients and MethodsWb-MRI was performed in 149 patients with aMM. The prognostic significance of the presence and absence, as well as the number, of FLs for progression into sMM was analyzed.ResultsFLs were present in 28% of patients. The presence per se of FLs and a number of greater than one FL were the strongest adverse prognostic factors for progression into sMM (P