STEREOCILIA DISPLACEMENT INDUCED SOMATIC MOTILITY OF COCHLEAR OUTER HAIR-CELLS
STEREOCILIA DISPLACEMENT INDUCED SOMATIC MOTILITY OF COCHLEAR OUTER HAIR-CELLS
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DOI：
10.1073/pnas.90.18.8347
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发表时间：
1993-09-15
影响因子：
11.1
通讯作者：
DALLOS, P
中科院分区：
文献类型：
--
作者：
EVANS, BN;DALLOS, P
从哺乳动物耳蜗分离出来的外毛细胞，已知通过延长或收缩细胞的圆柱体来对电刺激做出反应。据推测，当细胞在体内的感受器潜力驱动下，这种形状变化是耳蜗放大基础上的反馈过程的一部分。到目前为止，还不可能证明在正常的机械刺激下细胞的体形变化--即其毛束的偏转。我们在这里表明，机械诱导的发束偏转产生了细胞的体细胞运动。这种运动依赖于一个正常工作的正向转导过程，并在干扰转导时消失。这种能动的反应也反映了发束已知的方向敏感性。这种机械驱动运动的证明表明，细胞可能具有在其自身感受器电位的控制下影响其机械环境的能力，从而参与局部耳蜗反馈过程。
Outer hair cells, isolated from mammalian cochleas, are known to respond to electrical stimulation with elongation or contraction of the cell's cylindrical soma. It is assumed that such shape changes, when driven by the cell's receptor potential in vivo, are a part of the feedback process that underlies cochlear amplification. To date it has not been possible to demonstrate somatic shape changes upon normal mechanical stimulation of the cell-i.e., the deflection of its hair bundle. We show here that mechanically induced hair-bundle deflection produces somatic motility of the cell. Such motility is dependent upon a functioning forward transducer process and disappears upon interference with transduction. The motile response also reflects the hair bundle's known directional sensitivity. This demonstration of mechanically driven motility indicates that the cell may possess capabilities to affect its mechanical environment under control of its own receptor potential and, thereby, participate in a local cochlear feedback process.