Clinical characteristics of a concurrent condition of IgG4-RD and Castleman's disease
Clinical characteristics of a concurrent condition of IgG4-RD and Castleman's disease
复制标题
IgG4-RD 和 Castleman 病并发疾病的临床特征
DOI：
10.1007/s10067-018-4165-4
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发表时间：
2018-12-01
影响因子：
3.4
通讯作者：
Zhang, Wen
中科院分区：
文献类型：
--
作者：
Zhang, Xia;Zhang, Panpan;Zhang, Wen
IgG4-related disease (IgG4-RD) and Castleman's disease (CD) share similar clinical manifestations. When the histopathology coincides with the diagnosis of both IgG4-RD and CD, it is hard to depart the two disease entities utterly; here we call it IgG4-CD provisionally. In this study, we aim to review the clinical features of IgG4-CD. This study is based on a retrospective analysis of a prospectively acquired database. IgG4-CD was defined histopathologically in patients who fulfilled the diagnosis of both IgG4-RD and CD. Forty-five definite IgG4-RD and 16 multicentric CD (MCD) patients were recruited as controls. Clinical features including organ involvement, serum IgG4, IgG, IgE, ESR, CRP, and IL-6 levels were collected and analyzed. Fifteen patients (2.8%) out of 534 patients with IgG4-RD in China's largest prospective IgG4-RD and Mimicry cohort fulfilled the definition of IgG4-CD. There were 14 males and 1 female, whose mean age was 47 +/- 18years old, and the median disease duration before diagnosis was 12 (1-132) months. Eight patients have allergic disease history. IgG4-CD patients had more lymph node involvement (100 vs 57.8%, P
