Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease.
Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease.
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跨期决策的多巴胺调节：帕金森病的证据。
DOI：
10.1162/jocn_a_00929
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发表时间：
2016
影响因子：
3.2
通讯作者：
Shohamy,Daphna
中科院分区：
文献类型：
--
作者：
Foerde,Karin;Figner,Bernd;Doll,BradleyB;Woyke,IsabelC;Braun,ErinKendall;Weber,ElkeU;Shohamy,Daphna
在较小的即时奖励和较大的后期奖励之间进行选择是一个常见的选择问题，研究广泛认为受多巴胺严重支配的额纹状体回路是其中的核心。了解多巴胺如何调节跨期选择对于神经生物学模型和理解适应不良决策的机制具有重要意义。然而，多巴胺在跨期决策中的具体作用尚不清楚。多巴胺可能在跨期选择的多个方面发挥作用——选择结果的评估和对奖励延迟的敏感性。为了评估多巴胺在跨期决策中的作用，我们测试了纹状体多巴胺耗竭的帕金森病患者，其处于高（服药，PDON）或低（停药，PDOFF）多巴胺能状态。与 PDOFF 和健康对照相比，PDON 做出了更有远见的选择，并且随着奖励时间的增加而减少了其估值。此外，高多巴胺能状态下的折扣减少在多项指标中都很强劲，为多巴胺在未来决策中的作用提供了新的证据。
Choosing between smaller prompt rewards and larger later rewards is a common choice problem, and studies widely agree that frontostriatal circuits heavily innervated by dopamine are centrally involved. Understanding how dopamine modulates intertemporal choice has important implications for neurobiological models and for understanding the mechanisms underlying maladaptive decision-making. However, the specific role of dopamine in intertemporal decisions is not well understood. Dopamine may play a role in multiple aspects of intertemporal choices—the valuation of choice outcomes and sensitivity to reward delays. To assess the role of dopamine in intertemporal decisions, we tested Parkinson disease patients who suffer from dopamine depletion in the striatum, in either high (on medication, PDON) or low (off medication, PDOFF) dopaminergic states. Compared with both PDOFFand healthy controls, PDONmade more farsighted choices and reduced their valuations less as a function of increasing time to reward. Furthermore, reduced discounting in the high dopaminergic state was robust across multiple measures, providing new evidence for dopamine's role in making decisions about the future.