Nasal IgE production in allergic rhinitis: Impact of rhinovirus infection.
Nasal IgE production in allergic rhinitis: Impact of rhinovirus infection.
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过敏性鼻炎中鼻 IgE 的产生：鼻病毒感染的影响。
DOI：
10.1111/cea.13372
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Borish,Larry
中科院分区：
文献类型：
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作者：
Hamed,Ahmed;Preston,DeVonC;Eschenbacher,Will;Khokhar,Dilawar;Workman,Lisa;Steinke,JohnW;Heymann,Peter;Lawrence,Monica;Soto-Quiros,Manuel;Platts-Mills,ThomasAE;Payne,Spencer;Borish,Larry
研究背景：鼻病毒（RV）感染在一定程度上通过增强过敏状态加重哮喘，而这些加重可以通过抗IgE治疗来缓解。目的研究过敏性和非过敏性受试者鼻腔局部IgE产生的情况，并评估RV是否能增强这种情况。方法通过比较鼻部和血清中特异性IgE浓度与总IgE浓度的比值来测定局部特异性IgE的产生。我们最初的研究是在因过敏性和非过敏性呼吸道疾病就诊的患者中进行的。随后，我们研究了实验性RV感染对过敏队列鼻sIgE产生的影响。结果在过敏人群中，有30.3%的蝶翼飞蛾和14.6%的热带飞蛾有局部sIgE的产生。非过敏受试者均未出现局部IgE。活动性RV感染的受试者发生局部sIgE的可能性是前者的两倍多（45% vs 14%），产生局部sIgE的受试者发生哮喘加重的可能性是后者的3倍。实验性RV感染能够诱导局部sIgE的产生。结论：这些研究证实了大部分过敏性受试者存在局部IgE产生，并表明具有局部IgE的过敏性哮喘患者在感染RV后更容易发生哮喘加重。我们的RV挑战研究表明，至少一些过敏性哮喘患者在RV感染后可以诱导其鼻气道分泌局部生成的IgE。
BackgroundRhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state, and these exacerbations can be mitigated via administration of anti‐IgE.ObjectiveWe investigated the presence of local IgE production in the nose of allergic and non‐allergic subjects and assessed whether this was enhanced by RV.MethodsLocal production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples. Our initial studies were performed in subjects presenting to the emergency department for allergic and non‐allergic respiratory complaints. Subsequently, we investigated influences of experimental RV infection on nasal sIgE production in an allergic cohort.ResultsWe found evidence of local sIgE production toDermatophagoides pteronyssinusin 30.3% and toBlomia tropicalisin 14.6% of allergic subjects. None of the non‐allergic subjects demonstrated local IgE. Subjects with active RV infection were more than twice as likely to have local sIgE (45% vs 14%), and subjects with local sIgE being produced were ~3 times more likely to be having an asthma exacerbation. Experimental RV infection was able to induce local sIgE production.ConclusionThese studies confirm local IgE production in a large subset of allergic subjects and demonstrate that allergic asthmatics with local IgE are more likely to develop an asthma exacerbation when infected with RV. Our RV challenge studies demonstrate that at least some allergic asthmatics can be induced to secrete locally generated IgE in their nasal airway after RV infection.