Factors influencing serum CA125II levels in healthy postmenopausal women.
Factors influencing serum CA125II levels in healthy postmenopausal women.
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发表时间：
2001-05
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通讯作者：
D. Pauler;U. Menon;M. McIntosh;H. Symecko;S. Skates;I. Jacobs
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作者：
D. Pauler;U. Menon;M. McIntosh;H. Symecko;S. Skates;I. Jacobs
Our objective was to identify factors that correlate with CA125 concentrations in healthy postmenopausal women and to introduce recommendations for reporting and interpreting individual CA125 assay results. We analyzed repeated serum CA125 levels, as measured by the CA125II assay, in 18,748 postmenopausal women who participated in the ST: Bartholomew's/Royal London Hospital Ovarian Cancer screening trial from 1986 to 1994 and were not diagnosed with ovarian cancer during the 12-year follow-up period. We found that race is a substantial predictor of normal levels of CA125, with average CA125II concentration from African (median, 9.0; 95% range, 4.0-26.0 units/ml) and Asian women (median, 13.0; range, 5.9-33.3 units/ml) lower than that in Caucasian women (median, 14.2; range, 6.0-41.0 units/ml; P 0.05). We concluded that clinically significant differences in individual patient characteristics need to be reflected in the screening algorithms that use CA125II so that designed performance characteristics (sensitivity and specificity) are maintained in practice.
