Change and Recovery of Choroid Thickness after Short-term Application of 1% Atropine Gel and Its Influencing Factors in 6-7-year-old Children
Change and Recovery of Choroid Thickness after Short-term Application of 1% Atropine Gel and Its Influencing Factors in 6-7-year-old Children
复制标题
变化%20和%20恢复%20的%20脉络膜%20厚度%20后%20短期%20应用%20的%201%%20阿托品%20凝胶%20和%20其%20影响%20因素%20在%206-7岁%20儿童
DOI：
10.1080/02713683.2020.1863431
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发表时间：
2021-01-02
影响因子：
2
通讯作者：
Ke, Bilian
中科院分区：
文献类型：
--
作者：
Jiang, Yunjia;Zhang, Zhengwei;Ke, Bilian
摘要目的探讨6-7岁儿童短期应用1%阿托品凝胶后脉络膜厚度的变化和恢复情况及其影响因素。资料与方法71例儿童71只眼随机分为近视组和对照组。1%阿托品凝胶每天给药两次，持续一周，然后停药。在基线和第1、4、8周测量等效球镜（SE）、屈光度（AA）、角膜曲率（K）、眼轴长度（AL）和脉络膜厚度（CT）。使用光谱域光学相干断层扫描在中心凹下和距中心凹1 mm、2 mm和3 mm的颞侧、上级、鼻侧和下侧测量CT。结果1%阿托品治疗1周后，两组CT均随SE、AA、AL的变化而增加。他们逐渐恢复到基线水平7周后停药。近视组距中心凹上上级3 mm处的CT变化（Δ）显著高于对照组。在两组中，在基线和1周时，中心凹下的ΔCT与SE、AA和AL均无显著相关性。对照组黄斑中心凹下的ΔCT与ΔAL呈负相关。结论1%阿托品凝胶局部应用1周可使6-7岁儿童CT值增高。同时，退出后的恢复过程持续七周。在恢复过程中，两组的结构参数（AL、CT）和功能参数（AA、SE）的变化同步发生。基线时的SE、AA和AL可能无法预测阿托品对CT的影响程度。
ABSTRACT Purpose To investigate the change and recovery of choroid thickness after short-term application of 1% atropine gel and its influencing factors in 6-7-year-old children. Materials and Methods 71 right eyes of 71 children were enrolled and divided into myopia and control group. 1% atropine gel was administered twice a day for one week and then stopped. Spherical equivalent (SE), accommodative amplitude (AA), keratometry (K), axial length (AL), and choroidal thickness (CT) were obtained at baseline and 1st, 4th, and 8th weeks. CT was measured at subfovea and 1 mm, 2 mm, and 3 mm temporal, superior, nasal, and inferior from the fovea using spectral-domain optical coherence tomography. Results In both groups, all CTs increased following the change in SE, AA, and AL after administration of 1% atropine for one week. They gradually recovered to baseline levels seven weeks after withdrawal. The change (Δ) in CT at 3 mm superior from the fovea was significantly higher in the myopia group than in the control group. In both groups, ΔCT at subfovea had no significant correlation with SE, AA, and AL, both at baseline and one week. However, ΔCT at subfovea was negatively correlated with ΔAL in the control group. Conclusions One-week application of 1% atropine gel may increase CT in 6-7-year-old Chinese children. Meanwhile, the recovery process after withdrawal lasts seven weeks. During the recovery process, the changes in structural parameters (AL, CT) and functional parameters (AA, SE) in both groups occurred synchronously. The SE, AA, and AL at baseline may not predict the extent of atropine’s effect on CT.