Characterization of B7S3 as a Novel Negative Regulator of T Cells1
Characterization of B7S3 as a Novel Negative Regulator of T Cells1
复制标题
B7S3 作为 T 细胞新型负调节因子的表征1
作者：
Yang Yang;Xikui K. Liu;Thang Nguyen;C. Bishop;D. Graf;C. Dong
APC对T细胞的激活受B7样共刺激分子的调控。在这项研究中，我们描述了一个新的B7超家族成员，B7 S3，有两个不同的剪接异构体在淋巴和非淋巴组织中表达。可溶性B7 S3-IG蛋白与专职APC组成型结合以及与活化但非初始T细胞结合。B7 S3-IG处理显著抑制T细胞增殖和IL-2产生。B7 S3-IG还减少效应T细胞的细胞因子产生。有趣的是，虽然人类基因组似乎含有单拷贝B7 S3同源物，但小鼠B7 S3基因在2-Mb区域内有10个亲属，构成B7 S3基因家族。这项研究确定B7 S3作为一种新的T细胞负调节因子，并提出了在哺乳动物中进化上不同的T细胞调节机制。
T cell activation by APCs is regulated by B7-like costimulatory molecules. In this study, we describe a new B7 superfamily member, B7S3, with two differentially spliced isoforms expressed in lymphoid and nonlymphoid tissues. A soluble B7S3-Ig protein bound to professional APC constitutively as well as to activated but not naive T cells. B7S3-Ig treatment greatly inhibited T cell proliferation and IL-2 production. B7S3-Ig also reduced cytokine production by effector T cells. Interestingly, although human genome appears to contain a single-copy B7S3 homolog, the mouse B7S3 gene has 10 relatives within a 2-Mb region constituting a B7S3 gene family. This study identifies B7S3 as a novel negative regulator of T cells, and suggests evolutionarily divergent T cell regulation mechanisms in mammals.
影响因子：
32.4
作者：
Swallow, MM;Wallin, JJ;Sha, WC
通讯作者：
Sha, WC