Computer Optimization of Formulation of Flufenamic Acid/Polyvinylpolypyrrolidone/Methyl Cellulose Solid Dispersions
Computer Optimization of Formulation of Flufenamic Acid/Polyvinylpolypyrrolidone/Methyl Cellulose Solid Dispersions
复制标题
氟芬那酸/聚乙烯聚吡咯烷酮/甲基纤维素固体分散体配方的计算机优化
DOI：
10.1248/cpb.31.4496
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
T. Nagai
中科院分区：
文献类型：
--
作者：
K. Takayama;N. Nambu;T. Nagai
采用计算机优化技术，获得了氟芬那酸(FFA)/聚乙烯聚吡咯烷酮(PVPP)/甲基纤维素（MC）固体分散体，该分散体具有高溶出率和高稳定性。以PVPP、MC和乙醇为自变量。PVPP和MC都是配方变量，而用于制备固体分散体的乙醇是工艺变量。选取12个溶出度参数作为因变量，确定最佳配方。通过自变量的最佳组合对溶出度参数进行了定量预测。利用等高线图确定了各溶出度参数回归方程的物理意义。通过对回归方程进行约束，得到了FFA/PVPP/MC固体分散体的最佳配方。实验结果与预测结果吻合较好。
A computer optimization technique was applied to obtain flufenamic acid (FFA)/polyvinylpolypyrrolidone (PVPP)/methyl cellulose (MC) solid dispersions which provide a high dissolution rate and high stability of FFA. The amounts of PVPP, MC and ethanol were selected as independent variables. Both PVPP and MC are formulation variables, and ethanol, which was used for the preparation of solid dispersions, is a process variable. Twelve dissolution parameters were selected as dependent variables for deciding the optimum formulation. These dissolution parameters were predicted quantitatively by the best combination of independent variables. The physical significance of the regression equation for each dissolution parameter was defined with the application of contour graphs. The optimum formulation of FFA/PVPP/MC solid dispersions was obtained by placing a set of restrictions on the regression equations. Experimental results for the optimum formulation agreed well with the predictions.