The NF-κB/Rel family of transcription factors in oncogenic transformation and apoptosis
The NF-κB/Rel family of transcription factors in oncogenic transformation and apoptosis
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DOI：
10.1016/s1383-5742(99)00089-7
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发表时间：
1999-11-01
影响因子：
5.3
通讯作者：
Hofer-Warbinek, R
中科院分区：
文献类型：
--
作者：
de Martin, R;Schmid, JA;Hofer-Warbinek, R
最近的进展，导致激活NF-κ B家族转录因子的蛋白激酶和衔接子分子的鉴定和功能分析，导致一个相当详细的了解的主要信号通路之一，介导细胞的反应，在各种宿主防御的情况下，环境压力。NF-κ B被认为是介导基因协调表达的关键调节因子，所述基因是细胞机制的一部分，其功能是保护生物体免受物理、化学或微生物毒素造成的损伤。在多种病理生理情况下，例如免疫和炎症反应，细胞因子、白细胞介素和粘附分子在免疫系统细胞（包括T和B细胞、内皮细胞以及吞噬细胞/抗原呈递细胞）中的表达在很大程度上受NF-κ B调节。此外，这种转录因子似乎在细胞凋亡的调节中发挥核心作用，细胞凋亡是一种重要的细胞程序，不仅在胚胎发育期间而且在从正常到转化表型的过程中决定细胞的命运。因此，NF-κ B也已成为在多种病理情况下，包括慢性炎症和自身免疫性疾病、HIV感染和癌症中进行治疗性干预的有吸引力的靶标。(C)1999 Elsevier Science B. V.保留所有权利。
Recent progress in the identification and functional analysis of protein kinases and adapter molecules that lead to activation of NF-KB family transcription factors has lead to a quite detailed understanding of one of the major signalling pathways that mediate a cell's response to environmental stress in a variety of host-defense situations. NF-kappa B is recognized as a key regulatory factor mediating the coordinate expression of genes which are part of the cellular machinery that functions to protect an organism against damage posed by physical, chemical or microbial noxae. in a wide variety of patho-physiological situations such as immune and inflammatory reactions, the expression of cytokines, interleukins and adhesion molecules in cells of the immune system including T and B cells, endothelial as well as phagocytic/antigen presenting cells is to a large extent regulated by NF-kappa B. Moreover, this transcription factor appears to play a central role in the regulation of apoptosis, an important cellular program that decides upon a cell's fate not only during embryonic development but also on its way from normal to the transformed phenotype. Thus, NF-kappa B has emerged also as an attractive target for therapeutic interference in a variety of pathological situations, including chronic inflammatory and autoimmune diseases, HIV infection and cancer. (C) 1999 Elsevier Science B.V. All rights reserved.