Central blood volume and blood pressure in conscious primates.
Central blood volume and blood pressure in conscious primates.
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有意识的灵长类动物的中心血容量和血压。
DOI：
10.1152/ajpheart.1988.254.4.h693
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
McCulloch,T
中科院分区：
文献类型：
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作者：
Cornish,KG;Gilmore,JP;McCulloch,T
本研究对清醒的完全猴(I)和去窦弓神经的猴(SAD)进行了研究，以确定当静脉回流因出血(H)或下体负压(LBNP)减少时，高压受体对维持动脉血压(BP)的作用程度。在I组动物中，平均血压直到去除估计血容量(EBV)的5%时才显著降低，而随着去窦主动脉神经的发生，当EBV去除不到2%时，平均BP显著降低。两组动物的左房压力(LAP)降低程度相似。I组下体负压时平均血压无明显变化，而脉压在下体负压降至-5cmH2O时显著下降。在SAD动物中，当下体负压为-2cmH2O时，平均血压显著下降，当下体负压为-5cmH2O时，平均血压从134.1+/-4下降到102.7+/-7毫米汞。在两组动物中，LAP的下降幅度相似。这些数据支持这样一种观点，即静脉回流的非降压减少充分地卸载了动脉压力感受器，可能通过降低脉压来激活动脉压力感受器反射。此外，当LBNP或非低血压出血导致静脉回流减少时，低压受体本身似乎对维持血压没有重要作用。
Conscious intact (I) and sinoaortic-denervated monkeys (SAD) were studied to determine the extent to which high-pressure receptors contribute to the maintenance of arterial blood pressure (BP) when venous return is decreased by hemorrhage (H) or lower body negative pressure (LBNP). In the I animals, mean BP did not decrease significantly until 5% of the estimated blood volume (EBV) was removed, whereas, with sinoaortic denervation, mean BP decreased significantly when less than 2% of EBV was removed. Left atrial pressure (LAP) decreased similarly in both groups of animals. In the I group during LBNP, mean BP did not change significantly, whereas pulse pressure decreased significantly when LBNP was decreased to -5 cmH2O. In the SAD animals, mean BP decreased significantly at an LBNP of -2 cmH2O, and at -5 cmH2O mean BP declined from 134.1 +/- 4 to 102.7 +/- 7 mmHg. LAP decreased similarly in both groups of animals. The data support the view that a nonhypotensive reduction in venous return unloads arterial baroreceptors sufficiently to activate the arterial baroreflex, probably through reductions in pulse pressure. In addition, low-pressure receptors by themselves do not appear to contribute importantly to blood pressure maintenance when venous return is decreased by either LBNP or a nonhypotensive hemorrhage.