Sympathetic neural activation in visceral obesity
Sympathetic neural activation in visceral obesity
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DOI：
10.1161/01.cir.0000041244.79165.25
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发表时间：
2002-11-12
期刊：
影响因子：
37.8
通讯作者：
Davy, KP
中科院分区：
文献类型：
--
作者：
Alvarez, GE;Beske, SD;Davy, KP
背景-肌肉交感神经活动（MSNA）在肥胖人群中升高。然而，尚未探讨腹部内脏脂肪作为将肥胖与MSNA升高联系起来的重要脂肪组织储存库的潜在作用。因此，我们检验了MSNA在男性中会增加的假设，（年龄=18至40岁，体重指数小于或等于35 kg/m2），腹部内脏脂肪较高（HAVF; n=13，腹部内脏脂肪=118.1+/-15.8 cm（2））与年龄相比-（28.7 ± 2.4岁vs 25.5 ± 2.0岁，P>0.05），总脂肪量匹配（20.6 ± 2.1 vs 20.8 ± 2.4 kg，P>0.05）和腹部皮下脂肪匹配（230.6 ± 24.9 vs 261.4 ± 34.8 cm（2），P>0.05）下腹部内脏脂肪水平的同龄人（LAVF; n=13，内脏脂肪=73.0+/-6.0 cm（2））。方法和结果-MSNA（显微神经造影术），身体成分（双能X线吸收法），腹部内脏和皮下脂肪（计算机断层扫描）进行了测量，在37个久坐的男性在广泛的肥胖。HAVF男性患者的MSNA比LAVF男性患者高约55%（33+/-4 vs 21+/-2次/min，P
Background-Muscle sympathetic nerve activity (MSNA) is elevated in obese humans. However, the potential role of abdominal visceral fat as an important adipose tissue depot linking obesity to elevated MSNA has not been explored. Accordingly, we tested the hypothesis that MSNA would be increased in men (age=18 to 40 years, body mass index less than or equal to35 kg/m(2)) with higher abdominal visceral fat (HAVF; n=13, abdominal visceral fat=118.1+/-15.8 cm(2)) compared with their age- (28.7+/-2.4 versus 25.5+/-2.0 years, P>0.05), total fat mass-matched (20.6+/-2.1 versus 20.8+/-2.4 kg, P>0.05) and abdominal subcutaneous fat-matched (230.6+/-24.9 versus 261.4+/-34.8 cm(2), P>0.05) peers with lower abdominal visceral fat levels (LAVF; n=13, visceral fat=73.0+/-6.0 cm(2)).Methods and Results-MSNA (microneurography), body composition (dual energy x-ray absorptiometry), and abdominal visceral and subcutaneous fat (computed tomography) were measured in 37 sedentary men across a wide range of adiposity. MSNA was approximate to55% higher in men with HAVF compared with men with LAVF (33+/-4 versus 21+/-2 bursts/min, P