IL-6 detection in multiple sclerosis brain
IL-6 detection in multiple sclerosis brain
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DOI：
10.1016/s0022-510x(96)00283-3
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发表时间：
1997-02-27
影响因子：
4.4
通讯作者：
Annunziata, P
中科院分区：
文献类型：
--
作者：
Maimone, D;Guazzi, GC;Annunziata, P
应用免疫组织化学双标记技术，观察了6例多发性硬化症(MS)患者脑内急慢性活动斑块中IL-6的表达。IL-6主要与星形胶质细胞有关，与巨噬细胞或单核细胞浸润性细胞少见。IL-6免疫反应的分布模式与人类白细胞抗原-DR的表达模式相似，但这两种分子几乎从不共定位于同一细胞。我们的数据表明，在MS的中枢神经系统中，IL-6主要定位于常驻胶质细胞内，这些胶质细胞集中在正在进行的脱髓鞘和免疫激活的部位。尽管IL-6表现出几种促炎活性，但间接证据表明，细胞因子在炎性脱髓鞘疾病中也可能起到免疫调节作用。(C)1997年爱思唯尔科学公司。
By using a double-label immunohistochemistry technique, we demonstrated the presence of interleukin-6 (IL-6) in acute and chronic active plaques from the brain of six patients with multiple sclerosis (MS). IL-6 was mainly associated with astrocytes and rarely with macrophages or mononuclear infiltrating cells. The pattern of distribution for IL-6 immunoreactivity was similar to that of HLA-DR expression, but the two molecules almost never colocalized on the same cell. Our data indicate that in MS central nervous system IL-6 is predominantly located within resident glial cells which are concentrated at the sites of ongoing demyelination and immune activation. Although IL-6 exhibits several proinflammatory activities, indirect evidence suggests that the cytokine may also play an immunomodulatory role in inflammatory demyelinating disorders. (C) 1997 Elsevier Science B.V.