Evaluation of serum interleukin-10 levels as a predictor of glycemic alteration in chronic periodontitis and type 2 diabetes mellitus.
Evaluation of serum interleukin-10 levels as a predictor of glycemic alteration in chronic periodontitis and type 2 diabetes mellitus.
复制标题
评估血清白介素-10水平作为慢性牙周炎和2型糖尿病的血糖改变的预测指标。
DOI：
10.4103/0972-124x.150876
复制
发表时间：
2015-07
影响因子：
--
通讯作者：
Muddapur MV
中科院分区：
文献类型：
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作者：
Acharya AB;Thakur S;Muddapur MV
慢性牙周病（CPD）和2型糖尿病（T2 DM）有共同的致病途径。本研究旨在评估血清白细胞介素（IL-10）水平，这是一种与T2 DM相关的抗炎细胞因子，并评估其与高血糖症的相关性。本研究涉及60名参与者，分为4组，每组15名参与者：第1组（健康对照）、第2组（CPD患者）、第3组（T2 DM伴CPD患者）和第4组（T2 DM患者）。测量菌斑指数、牙龈指数、牙周袋探诊深度（PPD）、临床附着丧失、探诊出血、随机血糖、糖化血红蛋白（HbA 1c）和血清IL-10。IL-10在所有四组中均被检测到。所有组中的大多数变量均观察到统计学显著性差异（P < 0.05）。IL-10与第1组的PPD显著相关，与第4组的HbA 1c显著相关。IL-10在第1组中随PPD消退，在第4组中随HbA 1c消退。与第4组相比，第3组中的IL-10水平较低，第2组中最低。低IL-10水平与高HbA 1c相关。CPD的致病机制似乎调节IL-10。血清IL-10水平可能是预测SLE的指标之一。
Chronic periodontal disease (CPD) and type 2 diabetes mellitus (T2DM) share common pathogenic pathways. This study aimed to estimate levels of serum interleukin (IL-10), an anti-inflammatory cytokine also associated with T2DM and evaluate its association with hyperglycemia. This investigation involved sixty participants divided into four groups comprising 15 participants each: Group 1 (healthy controls), Group 2 (CPD patients), Group 3 (T2DM patients with CPD) and Group 4 (T2DM patients). Plaque index, gingival index, probing pocket depths (PPD), clinical attachment loss, bleeding on probing, random blood sugar, glycosylated hemoglobin (HbA1c), and serum IL-10 was measured. Interleukin-10 was detected in all four groups. Statistically significant (P < 0.05) differences were observed in most of the variables in all groups. IL-10 correlated significantly with PPD in Group 1 and with HbA1c in Group 4. IL-10 regressed with PPD in Group 1 and with HbA1c in Group 4. IL-10 levels were lower in Group 3 when compared with Group 4 and was lowest in Group 2. Low IL-10 levels associated with high HbA1c. Pathogenic mechanisms of CPD seem to regulate IL-10. Serum IL-10 levels may be one of the predictors of glycemia.