Three new anthraquinones from the twigs of Cassia fistula and their bioactivities
Three new anthraquinones from the twigs of Cassia fistula and their bioactivities
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决明枝中三种新的蒽醌化合物及其生物活性
DOI：
10.1080/10286020.2017.1285911
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发表时间：
2017-01-01
影响因子：
1.7
通讯作者：
Hu, Qiu-Fen
中科院分区：
文献类型：
--
作者：
Zhou, Min;Xing, Huan-Huan;Hu, Qiu-Fen
从决明的小枝中分离出三种以前未报道的蒽醌，瘘管醌 A-C (1-3)，以及三种已知的蒽醌 (4-6)。它们的结构是通过广泛的核磁共振和质谱分析确定的。对所有分离的化合物进行了抗烟草花叶病毒（抗TMV）活性测试，化合物3显示出显着的活性，在20M浓度下抑制率为34.5%，甚至比阳性对照更有效。此外，化合物1-6对一些测试的人类肿瘤细胞系表现出中等的细胞毒性，IC50值范围为2.8至9.4M。
Three previously unreported anthraquinones, fistulaquinones A-C (1-3), together with three known ones (4-6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20M concentration, even more potent than positive control. Additionally, compounds 1-6 exhibited moderate cytotoxicity with IC50 values ranging from 2.8 to 9.4M for some tested human tumor cell lines.