Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults
Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults
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DOI：
10.1159/000101340
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Bondi, Mark W.
中科院分区：
文献类型：
--
作者：
Jak, Amy J.;Houston, Wes S.;Bondi, Mark W.
背景/目的：由于研究结果相互矛盾，我们试图更好地确定载脂蛋白E(APOE)基因、海马体体积和非痴呆老年人认知能力之间的关系。方法：根据APOE-epsilon-4等位基因状态，对两组老年人进行两次结构性MRI和综合神经心理测试，平均相隔17个月。结果：APOE组的横断面比较显示，尽管携带APOE epsilon 4等位基因的人，海马体体积的纵向百分比减少显著大于APOE组，但在海马区体积方面没有差异。轻度认知障碍的诊断对海马体体积和记忆表现之间的关系有很大影响。结论：APOE epsilon 4等位基因似乎显著影响非痴呆老年人海马区随时间推移的体积丢失率，为了可靠地解释认知与脑结构之间的关系，样本的详细认知特征是必要的。版权所有(C)2007 S.Karger AG，巴塞尔。
Background/Aims: Because of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E ( APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults. Methods: Two groups of older adults, as determined by their APOE epsilon 4 allele status, received structural MRI and comprehensive neuropsychological testing on two occasions separated on average by 17 months. Results: Cross-sectional comparisons by APOE group revealed no differences in hippocampal volumes, although longitudinal percent reduction in hippocampal volume was significantly greater for those possessing the APOE epsilon 4 allele. Relationship between hippocampal volumes and memory performance was strongly impacted by diagnosis of mild cognitive impairment. Conclusions: APOE epsilon 4 allele appears to significantly impact rate of volume loss over time in the hippocampus in nondemented older adults, and detailed cognitive characterization of the sample is necessary to reliably interpret the relationship between cognition and brain structure. Copyright (c) 2007 S. Karger AG, Basel.