Association of salivary immunoglobulin A antibody and initial mutans streptococcal infection.
Association of salivary immunoglobulin A antibody and initial mutans streptococcal infection.
复制标题
唾液免疫球蛋白 A 抗体与初始变形链球菌感染的关联。
DOI：
10.1111/j.1399-302x.1998.tb00708.x
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发表时间：
1998
影响因子：
--
通讯作者：
Taubman,MA
中科院分区：
文献类型：
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作者：
Smith,DJ;King,WF;Akita,H;Taubman,MA
我们探讨了变形链球菌感染与初始定植期间唾液 IgA 抗体形成之间的关系。对 33 名儿童的牙齿进行重复擦拭（n=292）后发现，45% 的儿童在 13 至 36 个月大时感染了变形链球菌。相比之下，在 18 名儿童中未检测到变形链球菌，这些儿童的最后一次样本采集时间为 39-81 个月（中位年龄=62 个月）。在变形链球菌感染期间，无论是否已证实感染，大多数儿童都会出现针对几种变形链球菌抗原的免疫球蛋白A（IgA）抗体。对变形链球菌成分的强烈反应发生在变形链球菌感染期间或之后不久，但不是之前。尽管个体受试者的 IgA 蛋白质印迹模式通常非常不同，但在感染和未感染儿童组的总结反应模式中没有观察到一致的差异。例如，一些兄弟姐妹被认为受到相似的母体变形链球菌克隆型的挑战，但它们对变形链球菌成分产生了性质不同的唾液 IgA 反应。这些结果支持变形链球菌感染的一个离散时期，并可能表明母体感染水平是该时期儿童成功感染的一个因素。数据还表明，在感染期间，接触变形链球菌是对变形链球菌抗原产生强烈粘膜 IgA 反应的充分条件，并且这些反应可能不同，即使在兄弟姐妹之间也是如此。
We explored the relationship between mutans streptococcal infection and the development of salivary IgA antibody during initial colonization. Repetitive swabbing (n= 292) of the teeth of 33 children revealed that 45% became infected with mutans streptococci between 13 and 36 months of age. In contrast, mutans streptococci could not be detected in 18 children whose last sample was taken at 39–81 months of age (median age=62 months). During the period of mutans streptococcal infectivity, immunoglobulin A (IgA) antibody to several mutans streptococcal antigens appeared in most children, whether or not infection had been demonstrated. Robust responses to mutans streptococcal components occurred during or shortly after, but not before the period of mutans streptococcal infectivity. No consistent differences were observed among the summarized patterns of response of infected and uninfected groups of children, although the IgA Western blot patterns of individual subjects were often quite distinct. For example, sets of siblings, who would be presumed to be challenged with similar maternal mutans streptococcal clonotypes, were shown to develop qualitatively different salivary IgA responses to mutans streptococcal components. These results support a discrete period for mutans streptococcal infection and may suggest that the level of maternal infection is a factor in the success of infection of the child during this period. The data also suggest that exposure to mutans streptococci is a sufficient condition for robust mucosal IgA responses to mutans streptococcal antigens during the period of infectivity and that these responses may be different, even among siblings.