Endomorphin-2 modulates productions of TNF-α, IL-1β, IL-10, and IL-12, and alters functions related to innate immune of macrophages
Endomorphin-2 modulates productions of TNF-α, IL-1β, IL-10, and IL-12, and alters functions related to innate immune of macrophages
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DOI：
10.1023/a:1019766602138
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发表时间：
2002-10-01
期刊：
影响因子：
5.1
通讯作者：
Ohura, K
中科院分区：
文献类型：
--
作者：
Azuma, Y;Ohura, K
我们评估了阿片肽内啡肽-2对大鼠腹腔巨噬细胞炎症和Th1/Th2平衡相关细胞因子产生以及先天免疫相关功能的免疫作用。内啡肽-2抑制tnf - α、IL-10和IL-12的产生，但增强巨噬细胞产生il -1 β。此外，内啡肽-2增强了巨噬细胞对纤维连接蛋白的粘附，以及巨噬细胞粘附分子Mac-1的表达。相比之下，内啡肽-2抑制巨噬细胞对调理大肠杆菌的吞噬，而不影响非调理大肠杆菌的吞噬。此外，内啡肽-2抑制巨噬细胞趋化，并抑制巨噬细胞产生超氧阴离子。这些结果表明，内啡肽-2可能改变巨噬细胞的功能，如细胞因子的产生和与先天免疫相关的功能。
We evaluate immunological effects of opioid peptide endomorphin-2 on the production of cytokines related to inflammation and Th1/Th2 balance, and functions related to innate immune of rat peritoneal macrophages. Endomorphin-2 inhibited TNF-alpha, IL-10, and IL-12 productions, but potentiated IL-1beta production by macrophages. Moreover, endomorphin-2 potentiated macrophage adhesion to fibronectin, and the expression of adhesion molecule Mac-1 on macrophages. In contrast, endomorphin-2 suppressed phagocytosis of opsonized E. coli by macrophages, without affecting phagocytosis of non-opsonized E. coli. In addition, endomorphin-2 inhibited macrophage chemotaxis, and the production of superoxide anion by macrophages. These results suggest that endomorphin-2 may alter macrophage functions such as cytokine productions and functions related to innate immune.