Global average gray and white matter N-acetylaspartate concentration in the human brain
Global average gray and white matter N-acetylaspartate concentration in the human brain
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DOI：
10.1016/j.neuroimage.2008.02.034
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发表时间：
2008-06-01
期刊：
影响因子：
5.7
通讯作者：
Gonen, Oded
中科院分区：
文献类型：
--
作者：
Inglese, Matilde;Rusinek, Henry;Gonen, Oded
由于氨基酸衍生物N-乙酰天冬氨酸(NAA)几乎是成年哺乳动物脑内神经细胞所独有的，其浓度在大多数局灶性(或弥漫性)神经系统疾病中显示出局部(或整体)异常，因此被认为是一种特异的神经元标记物。然而，尽管NAA在生物学和临床上具有显着性意义，但灰质和白质(GM，WM)中NAA的相对浓度仍然存在争议，据报道，两者都高于、等于或低于另一种。为了帮助解决争议，更重要的是，获取两个区的NAA的整体，我们引入了一种新的方法，通过结合MR图像分割、定位和非定位定量H-1-MRS来区分和量化全脑平均GM和WM NAA浓度。我们在10名健康志愿者(5名女性)身上演示并验证了该方法，这些志愿者在1.5T时年龄为27+/-6岁(平均+/-标准差)。结果表明，健康成人脑中WM的体积为39+/-3%，明显少于GM60+/-4%(p<；0.01)。此外，WM组的NAA平均浓度为9.5+/-1.0 mM，显著低于GM组的14.3+/-1.1 mM(p<；0.01)。(C)2008 Elsevier Inc.保留所有权利。
Since the amino acid derivative N-acetylaspartate (NAA) is almost exclusive to neuronal cells in the adult mammalian brain and its concentration has shown local (or global) abnormalities in most focal (or diffuse) neurological diseases, it is considered a specific neuronal marker. Yet despite its biological and clinical prominence, the relative NAA concentration in the gray and white matter (GM, WM) remains controversial, with each reported to be higher than, equal to, or less than the other. To help resolve the controversy and importantly, access the NAA in both compartments in their entirety, we introduce a new approach to distinguish and quantify the whole-brain average GM and WM NAA concentration by integrating MR-image segmentation, localized and non-localized quantitative H-1-MRS. We demonstrate and validate the method in ten healthy volunteers (5 women) 27 +/- 6 years old (mean +/- standard-deviation) at 1.5T. The results show that the healthy adult human brain comprises significantly less WM, 39 +/- 3%, than GM 60 +/- 4% by volume (p < 0.01). Furthermore, the average NAA concentration in the WM, 9.5 +/- 1.0 mM, is significantly lower than in GM, 14.3 +/- 1.1 mM (p < 0.01). (c) 2008 Elsevier Inc. All rights reserved.