SOCIAL NEUROSCIENCE - AUTONOMIC, NEUROENDOCRINE, AND IMMUNE-RESPONSES TO STRESS
SOCIAL NEUROSCIENCE - AUTONOMIC, NEUROENDOCRINE, AND IMMUNE-RESPONSES TO STRESS
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DOI：
10.1111/j.1469-8986.1994.tb01032.x
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发表时间：
1994-03-01
期刊：
影响因子：
3.7
通讯作者：
CACIOPPO, JT
中科院分区：
文献类型：
--
作者：
CACIOPPO, JT
免疫系统受到社会和心理因素影响的中枢神经系统过程的影响。因此，对社会因素、内心过程和自主心理生理学的考虑可能有助于更全面地了解免疫和大脑功能。这里回顾的研究（a）检查了对短暂和慢性压力源的反应做出贡献或调节的社会情绪因素，（b）确定心率反应性的稳定个体差异是否可以预测对短暂心理压力源和流感病毒疫苗的神经内分泌和免疫反应，以及（c）研究低和高心率反应性个体差异的自主起源及其与对慢性和急性压力源的神经内分泌和免疫反应的关系。我们的研究结果包括：（a）急性心理压力会激活个体的交感肾上腺髓质系统并影响免疫功能； (b) 具有对急性心理应激源的高交感心脏反应性的个体也表现出下丘脑垂体肾上腺皮质系统的相对激活和免疫功能的改变。
The immune system is influenced by central nervous system processes that are shaped by social and psychological factors. Considerations of social factors, intrapersonal processes, and autonomic psychophysiology therefore may contribute to a fuller understanding of both immune and brain function. Research reviewed here (a) examines the socioemotional factors that contribute to, or moderate, responses to brief and chronic stressors, (b) determines whether or not stable individual differences in heart rate reactivity predict neuroendocrine and immune responses to a brief psychological stressor and to an influenza virus vaccine, and (c) investigates the autonomic origins of individual differences in low and high heart rate reactivity and their relationship to neuroendocrine and immune responses to chronic and acute stressors. Among our findings are: (a) acute psychological stressors activate the sympathetic adrenomedullary system across individuals and affect immune function; and (b) individuals characterized by high sympathetic cardiac reactivity to acute psychological stressors also show a relative activation of the hypothalamic pituitary adrenocortical system and altered immune function.