The arguments for pre-existing early and late endosomes.
The arguments for pre-existing early and late endosomes.
复制标题
DOI：
10.1016/0962-8924(91)90047-d
复制
发表时间：
1991-07-01
影响因子：
19
通讯作者：
Gruenberg, J
中科院分区：
文献类型：
--
作者：
Griffiths, G;Gruenberg, J
在过去的十年中，我们已经看到了许多事件和过程的阐明，这些事件和过程负责受体介导的内吞作用。然而，关于内吞途径的一个基本问题仍然没有解决：早期核内体是否成熟为晚期核内体，或者这是两个不同的和预先存在的细胞器？一般观点倾向于支持前一种可能性，以至于最近美国细胞生物学学会会议上的一个海报会议题为“内体的成熟”。这篇文章汇集了支持先前存在的早期和晚期核内体的新数据，它们之间的运输是通过囊泡出芽和融合发生的。
The past decade has seen the elucidation of many of the events and processes responsible for receptor-mediated endocytosis. However, a fundamental question about the endocytic pathway remains unresolved: do early endosomes mature into late endosomes, or are these two distinct and pre-existing cellular organelles? General opinion tends to favour the former possibility, to the point where one poster session at the recent American Society for Cell Biology meeting was entitled 'Maturation of Endosomes'. This article draws together new data arguing in favour of pre-existing early and late endosomes, between which transport occurs by vesicle budding and fusion.