Angiogenesis and lymphangiogenesis-implications for corneal immunity.
Angiogenesis and lymphangiogenesis-implications for corneal immunity.
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DOI：
10.1080/08820530500509358
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发表时间：
2006-01-01
影响因子：
1.7
通讯作者：
Dana, M Reza
中科院分区：
文献类型：
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作者：
Dana, M Reza
现在人们普遍认为，血管生成和免疫原性炎症在许多组织中存在错综复杂的关系。然而，鲜为人知的是，血液(血红素)血管生成(HA)和淋巴管生成(LG)在多大程度上受到不同程度的调控，进而可能对角膜抗原产生的获得性免疫产生不同方面的影响。在这里，我们将简要介绍这一领域的相关工作，特别是通过这两个不同的角膜血管生成过程对免疫的不同调节，说明尽管在诱导角膜这些血管生成过程的机制中存在显著的冗余，但在它们促进免疫的哪些方面也存在重要的区别。
It is now widely acknowledged that vasculogenesis and immunogenic inflammation are intricately related in many tissues. However, less understood is to what extent blood (heme) angiogenesis (HA) and lymphangiogenesis (LG) are differentially regulated, and in turn contribute potentially to different aspects of adaptive immunity generated to corneal antigens. Herein, we will provide a brief synopsis of relevant work in this field by focusing particularly on the differential regulation of immunity by these two distinct vasculogenic processes in the cornea, illustrating that in spite of significant redundancies in the mechanisms that induce these vascular processes in the cornea, there are also important distinctions in what aspects of immunity are promoted by them.