EEG indices of tonic pain-related activity in the somatosensory cortices
EEG indices of tonic pain-related activity in the somatosensory cortices
复制标题
DOI：
10.1016/j.clinph.2008.01.019
复制
发表时间：
2008-05-01
影响因子：
4.7
通讯作者：
Schuckers, Stephanie
中科院分区：
文献类型：
--
作者：
Downian, Robert;Rissacher, Daniel;Schuckers, Stephanie
目的：识别反映疼痛相关皮质活动的脑电图特征，并识别可以掩盖疼痛相关脑电图特征和/或产生可能被误解为疼痛特异性特征的因素。方法：在以平衡顺序呈现的三种条件下记录脑电图：强直性冷痛条件、疼痛预期和算术控制条件。当受试者做出皱眉的面部表情时，还记录了脑电图，以估计头皮肌电图伪影对疼痛相关脑电图特征的贡献。结果：在冷痛条件下，对侧颞部头皮的 Alpha 振幅减小，后部头皮的 Alpha 振幅增加。在冷痛状态下，大多数电极位置的伽马带活动增加，这是由于肌电图伪影所致。结论：冷痛期间对侧颞部头皮的 α 减少与初级体感皮层和/或位于顶叶和/或岛叶的体感关联区域的疼痛相关活动一致。这项研究还确定了可能掩盖疼痛相关脑电图特征和/或产生可能被误解为疼痛特异性脑电图特征的因素。这些包括（但不限于）由于注意力集中在疼痛上而导致视觉皮层中产生的阿尔法增加；伽马带活动普遍增加，这是由经常伴随疼痛的面部表情产生的头皮肌电图引起的；当受试者之间以相同的顺序给出疼痛和控制条件时，脑电图随时间的非特异性变化可能会掩盖与疼痛相关的脑电图特征。意义：本研究确定了需要控制和/或隔离的几个因素，以便成功记录反映体感皮层疼痛相关活动的脑电图特征。 (c) 2008 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: To identify EEG features that index pain-related cortical activity, and to identify factors that can mask the pain-related EEG features and/or produce features that can be misinterpreted as pain-specific.Methods: The EEG was recorded during three conditions presented in counterbalanced order: a tonic cold pain condition, and pain anticipation and arithmetic control conditions. The EEG was also recorded while the subjects made a wincing facial expression to estimate the contribution of scalp EMG artifacts to the pain-related EEG features.Results: Alpha amplitudes decreased over the contralateral temporal scalp and increased over the posterior scalp during the cold pain condition. There was an increase in gamma band activity during the cold pain condition at most electrode locations that was due to EMG artifacts.Conclusions: The decrease in alpha over the contralateral temporal scalp during cold pain is consistent with pain-related activity in the primary somatosensory cortex and/or the somatosensory association areas located in the parietal operculum and/or insula. This study also identified factors that might mask the pain-related EEG features and/or generate EEG features that could be misinterpreted as being pain-specific. These include (but are not limited to) an increase in alpha generated in the visual cortex that results from attention being drawn towards the pain; the widespread increase in gamma band activity that results from scalp EMG generated by the facial expressions that often accompany pain; and the possibility that non-specific changes in the EEG over time mask the pain-related EEG features when the pain and control conditions are given in the same order across subjects.Significance: This study identified several factors that need to be controlled and/or isolated in order to successfully record EEG features that index pain-related activity in the somatosensory cortices. (c) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.