Immunoarchitectural patterns of germinal center antigens including LMO2 assist in the differential diagnosis of marginal zone lymphoma vs follicular lymphoma.
Immunoarchitectural patterns of germinal center antigens including LMO2 assist in the differential diagnosis of marginal zone lymphoma vs follicular lymphoma.
复制标题
包括 LMO2 在内的生发中心抗原的免疫结构模式有助于边缘区淋巴瘤与滤泡性淋巴瘤的鉴别诊断。
DOI：
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复制
发表时间：
2013
影响因子：
3.5
通讯作者：
J. Cook
中科院分区：
文献类型：
--
作者：
K. Dyhdalo;Christopher P. Lanigan;R. Tubbs;J. Cook
目标
目的：研究生发中心（GC）相关标志物CD 10、BCL 6和LMO 2的免疫结构模式及其在边缘区淋巴瘤（MZL）与滤泡性淋巴瘤（FL）鉴别诊断中的应用。
方法
对42例累及淋巴结的MZL和88例FL进行了检查。
结果
滤泡间GC标记物染色在MZL中不常见，但在FL中常见，包括BCL 2阳性和BCL 2阴性病例。两种非典型的滤泡内GC染色模式被确定为在MZL中比在FL中更常见。
结论
除了CD10和BCL 6的LMO2染色有利于检测的GC表型在FL。淋巴结涉及MZL经常表现出GC免疫结构的特征性改变。识别这些改变的模式有助于区分MZL和FL。
OBJECTIVES
To examine the immunoarchitectural patterns of the germinal center (GC)-associated markers CD10, BCL6, and LMO2 and their utility in the differential diagnosis of marginal zone lymphoma (MZL) vs follicular lymphoma (FL).
METHODS
Forty-two cases of MZL involving lymph nodes and 88 cases of FL were examined.
RESULTS
Interfollicular staining for GC markers was uncommon in MZL but common in FL, including BCL2-positive and BCL2-negative cases. Two atypical patterns of intrafollicular GC staining were identified that were more common in MZL than in FL.
CONCLUSIONS
Staining for LMO2 in addition to CD10 and BCL6 facilitates the detection of a GC phenotype in FL. Lymph nodes involved by MZL frequently show characteristic alterations of GC immunoarchitecture. Recognizing these altered patterns assists in the distinction between MZL and FL.
HGAL 和 LMO2 在分离源自淋巴结和结外部位（包括骨髓）的小 B 细胞的淋巴瘤方面的功效。
影响因子：
3.5
作者：
Younes,SherenF;Beck,AndrewH;Ohgami,RobertS;Lossos,IzidoreS;Levy,Ronald;Warnke,RogerA;Natkunam,Yasodha
通讯作者：
Natkunam,Yasodha
影响因子：
20.3
作者：
Natkunam, Yasodha;Zhao, Shuchun;Levy, Ronald
通讯作者：
Levy, Ronald
III 级和滤泡性淋巴瘤的滤泡间浸润中 CD10 表达降低。
DOI：
10.1309/b6mk-j7nf-a6jp-x56k
发表时间：
2001
期刊：
American journal of clinical pathology.
影响因子：
--
作者：
Eshoa,C;Perkins,S;Kampalath,B;Shidham,V;Juckett,M;Chang,CC
通讯作者：
Chang,CC