Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning
Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning
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DOI：
10.1017/s000711450720580x
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发表时间：
2007-01-01
影响因子：
3.6
通讯作者：
Seve, Bernard
中科院分区：
文献类型：
--
作者：
Montagne, Lucile;Boudry, Gaelle;Seve, Bernard
我们分析了仔猪断奶后两周内肠道形态、生理和生态事件的时空序列，以提供有限数量的变量，这些变量可以作为断奶后肠道变化的相关标记。对60头仔猪进行实验，禁食2 d，断奶后给予中等或高含量小麦的断奶日粮，控制胃饲，并在断奶后不同时间点进行屠宰。通过主成分分析对六十九个变量进行了分析。结果表明，断奶引起的肠道时间变化可分为两个时期：断奶后立即发生的急性期，第 5 天后是更渐进的适应和成熟期。这种适应的主要因素是再喂养过程和时间，而饮食本身影响不大。绒毛长度、乳糖酶活性、穿过空肠的大分子通量和血浆胆囊收缩素被认为是急性期的标志。空肠质量、胰腺重量、胃内容物、空肠胰蛋白酶活性和茶碱分泌量与复饲有关。建议跟踪肠道成熟的标志物是回肠中的麦芽糖酶活性、葡萄糖吸收和基础阻力、结肠中的乳酸杆菌和肠球菌以及结肠和盲肠内容物的 pH 值。这些标记可能有助于设计合适的日粮，以限制猪断奶后肠道疾病。
We analysed the spatio-temporal sequence of events concerning the morphology, physiology and ecology of the gut of piglets during the 2 weeks following weaning, in order to provide a limited number of variables that could be relevant markers of the gut post-weaning changes. An experiment was conducted on sixty piglets fasted for 2 d, then administered a weaning diet with a moderate or a high content of wheat using controlled gastric feeding, and slaughtered at different time-points post-weaning. Sixty-nine variables were analysed by principal component analysis. The results showed that the temporal changes induced in the gut by weaning can be divided into two periods: an acute period happening immediately after weaning, followed after day 5 by a more progressive adaptative and maturational phase. The main factors of this adaptation were the refeeding process and the time, while the diet per se had little influence. The villus length, lactase activity, macromolecule fluxes across the jejunum and the plasma cholecystokinin were proposed as markers of the acute phase. The mass of the jejunum, the weight of the pancreas, the content of stomach, the trypsin activity and the theophylline-induced secretion in jejunum were related to the re-feeding. Markers proposed to follow the gut maturation were the maltase activity, the glucose absorption and the basal resistance in the ileum, the lactobacilli and enterococci in the colon, and the pH of colonic and caecal contents. These markers might be helpful to design suitable diets to limit post-weaning gut disorders in pigs.