Early and individualized goal-directed therapy for trauma-induced coagulopathy.

Early and individualized goal-directed therapy for trauma-induced coagulopathy.
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DOI:
10.1186/1757-7241-20-15
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发表时间:
2012-02-24
期刊:
Scandinavian journal of trauma, resuscitation and emergency medicine
影响因子:
--
通讯作者:
Voelckel W
Voelckel W
中科院分区:
其他
文献类型:
--
作者:
Schöchl H;Maegele M;Solomon C;Görlinger K;Voelckel W

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Severe trauma-related bleeding is associated with high mortality. Standard coagulation tests provide limited information on the underlying coagulation disorder. Whole-blood viscoelastic tests such as rotational thromboelastometry or thrombelastography offer a more comprehensive insight into the coagulation process in trauma. The results are available within minutes and they provide information about the initiation of coagulation, the speed of clot formation, and the quality and stability of the clot. Viscoelastic tests have the potential to guide coagulation therapy according to the actual needs of each patient, reducing the risks of over- or under-transfusion. The concept of early, individualized and goal-directed therapy is explored in this review and the AUVA Trauma Hospital algorithm for managing trauma-induced coagulopathy is presented.
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